63382-37-6Relevant articles and documents
Biosynthesis of the Enterotoxic Pyrrolobenzodiazepine Natural Product Tilivalline
Dornisch, Elisabeth,Pletz, Jakob,Glabonjat, Ronald A.,Martin, Florian,Lembacher-Fadum, Christian,Neger, Margit,H?genauer, Christoph,Francesconi, Kevin,Kroutil, Wolfgang,Zangger, Klaus,Breinbauer, Rolf,Zechner, Ellen L.
supporting information, p. 14753 - 14757 (2017/11/14)
The nonribosomal enterotoxin tilivalline was the first naturally occurring pyrrolobenzodiazepine to be linked to disease in the human intestine. Since the producing organism Klebsiella oxytoca is part of the intestinal microbiota and the pyrrolobenzodiaze
MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases)
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Page/Page column 28-30, (2010/11/08)
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Modulators of protein tyrosine phosphateses (PTPases)
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, (2008/06/13)
Disclosed are novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds of Formula 1 are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) including PTP1B, T cell PTP, wherein n, m, X, R1, R2, R3, R4, R5, R6, and R7are defined more fully in the description. The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, and other diseases.