63471-88-5 Usage
Description
4-(4-Butoxyphenyl)-4-oxobutanoic acid is an organic compound with the molecular formula C12H14O4. It is a derivative of butanoic acid, featuring a butoxyphenyl group attached to the fourth carbon. 4-(4-BUTOXYPHENYL)-4-OXOBUTANOIC ACID is known for its potential applications in the pharmaceutical industry, particularly in the development of inhibitors for Alzheimer's disease.
Uses
Used in Pharmaceutical Industry:
4-(4-Butoxyphenyl)-4-oxobutanoic acid is used as a key reagent for the synthesis of 3-amino-2-hydroxybutanamide derivatives. These derivatives act as β-secretase inhibitors, which are crucial in the treatment of Alzheimer's disease. By inhibiting the β-secretase enzyme, these derivatives can potentially slow down the progression of the disease and improve the quality of life for patients.
Check Digit Verification of cas no
The CAS Registry Mumber 63471-88-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,3,4,7 and 1 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 63471-88:
(7*6)+(6*3)+(5*4)+(4*7)+(3*1)+(2*8)+(1*8)=135
135 % 10 = 5
So 63471-88-5 is a valid CAS Registry Number.
InChI:InChI=1/C14H18O4/c1-2-3-10-18-12-6-4-11(5-7-12)13(15)8-9-14(16)17/h4-7H,2-3,8-10H2,1H3,(H,16,17)
63471-88-5Relevant articles and documents
Fenbufen, a new anti inflammatory analgesic: synthesis and structure activity relationships of analogs
Child,Osterberg,Sloboda,Tomcufcik
, p. 466 - 476 (2007/10/05)
100 analogs of fenbufen were prepared and tested using the carrageenan, polyarthritis, and UV erythema anti inflammatory tests and the 2 phenyl 1,4 benzoquinone writhing and inflamed paw pressure analgesic tests. Only 3 retained the same full spectrum of activity as fenbufen: dl 4 (4 biphenylyl) 4 hydroxybutyric acid, dl 4 (4 biphenylyl) 1,4 butanediol, and 4 biphenylacetic acid. Fenbufen had the same spectrum of activity as aspirin, phenylbutazone, and indomethacin in the 5 tests. In addition, dose response derived potencies show fenbufen more potent than aspirin and at least as potent as phenylbutazone in all 5 tests. Two related compounds were generally similar.