6362-58-9

Basic information

• Product Name: 3-Phenylpyruvic acid methyl ester
• Synonyms: 2-Oxo-3-phenylpropionic acid methyl ester;3-Phenylpyruvic acid methyl ester;α-Oxobenzenepropanoic acid methyl ester;methyl 2-oxo-3-phenylpropanoate;phenyl pyruvic acid methyl ester
• CAS NO: 6362-58-9
• Molecular Formula: C₁₀H₁₀O₃
• Molecular Weight: 178.18
• Mol File: 6362-58-9.mol
• Article Data: 17

Chemical Properties

• Melting Point: 115 °C
• Boiling Point: 152-154 °C(Press: 3 Torr)
• Appearance: /
• Density: 1.143±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 3-Phenylpyruvic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Phenylpyruvic acid methyl ester(6362-58-9)
• EPA Substance Registry System: 3-Phenylpyruvic acid methyl ester(6362-58-9)

Safety Data

• Hazardous Substances Data: 6362-58-9(Hazardous Substances Data)

Upstream product

• 186581-53-3 diazomethane 
• 156-06-9 2-oxo-3-(phenyl)propionic acid 
• 71663-73-5 β-Aminozimtsaeureethylester 
• 67-56-1 methanol 
• 5781-53-3 monomethyl oxalyl chloride 
• 1589-82-8 phenylmagnesium bromide 
• 100-52-7 benzaldehyde 
• 18020-59-2 methyl 3-hydroxy-2-methylidene-3-phenylpropionate 
• 3070-71-1 methyl 2-benzylacrylate 
• 124957-36-4 Methyl 3-acetoxy-2-methylene-3-phenylpropanoate 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 115794-66-6 trans-methyl 3-phenylglycidate 
• 21156-62-7 N-acetylphenylalanine methyl ester 
• 72015-61-3 (Z)-2-benzyloxycarbonylaminocinnamic acid 

Downstream Products

• 857819-80-8 2-benzyl-2-hydroxy-4-oxo-3-phenyl-glutaric acid 
• 87223-71-0 methyl (Z)-2-acetyloxy-3-phenyl-2-propenoate 
• 13674-16-3 methyl 2-hydroxy-3-phenylpropanoate 
• 100474-28-0 n-butyl 4-hydroxy-5-oxo-3-phenyl-2,5-dihydro-2-furan-carboxylate 
• 109872-99-3 Methyl 2,2-difluoro-3-phenylpropanoate 
• 100-52-7 benzaldehyde 
• 79617-87-1 erythro-3-fluoro-3-phenylalanine 
• 57362-93-3 threo-DL-β-fluorophenylalanine 
• 76532-83-7 3-fluoro-2-keto-3-phenylpropanoic acid methyl ester 
• 88867-13-4 erythro-N-Acetyl-3-fluorophenylalanine 
• 50877-94-6 methyl 2-(N-hydroxyimino)-3-phenylpropanoate 
• 15028-44-1 DL-phenylalanine methyl ester 
• 149818-98-4 methyl (R)-α-<<(1,1-dimethylethoxy)carbonyl>amino><1,1'-biphenyl>-4-propanoate 
• 1426129-50-1 N-[(1R)-2-[1,1'-biphenyl]-4-yl-1-(hydroxymethyl)ethyl]carbamic acid tert-butyl ester 

Relevant articles and documents

KINASE INHIBITOR

The present invention aims to provide a novel kinase inhibitor and the like, and a therapeutic agent for a disease, a drug discovery screening method and the like utilizing such inhibitor and the like. The compound represented by the following formula (I) and a salt thereof can inhibit plural kinases including LATS (particularly LATS2) which is the major kinase in the Hippo signal transduction pathway. In addition, diseases or tissue damage associated with failure of cellular proliferation can be treated. Therefore, the present invention is beneficial, for example, in the research field of cell functions and diseases, in which the Hippo signal transduction pathway is involved, and the like. Furthermore, it is beneficial in the medical field for the treatment of such diseases and the like. wherein each symbol is as defined in the DESCRIPTION.

Preparation method of LCZ696 intermediate

The invention discloses a preparation method of LCZ696 intermediate and relates to the technical field of preparation of an aromatic nucleus compound containing 2 benzene rings and 1 chiral center. The preparation method includes the steps of S1, allowing benzyl magnesium bromide to react with methyl oxalyl chloride to obtain a compound as shown in formula I; S2, allowing the compound as shown in formula I to have a bromination reaction with a bromination reagent to generate a compound as shown in formula II; S3, coupling the compound as shown in formula II with phenylboronic acid to obtain a compound as shown in formula III; S4, performing reductive ammoniation on the compound as shown in formula III to obtain a compound as shown in formula IV; S5, applying Boc to the compound as shown in formula IV to obtain a compound as shown in formula V; S6, performing ester group reduction on the compound as shown in formula V to obtain a compound as shown in formula VI. The preparation method has the advantages that overall raw material consumption is lowered, and product productivity and market competiveness are increased; by the overall process optimization, the reaction of each step can be performed and controlled easily, the use of heavy metal catalysts is reduced and avoided, and accordingly the quality index of the final product is increased, and an economic and environment-friendly process route is developed.

Dorsamin-A's, glycerolipids carrying a dehydrophenylalanine ester moiety from the seed-eating larvae of the bruchid beetle Bruchidius dorsalis

Using a TLC autographic assay for radical-scavenging activity with the ABTS radical, the presence of lipophilic antioxidants in the larvae of the wild bruchid seed beetle Bruchidius dorsalis was detected. Assay-guided fractionation of the CHCl3-soluble fraction of the larvae resulted in the isolation of new glycerolipids, designated dorsamin-A763, -A737, -A765, -A739, and -A767, comprising 1,2-diacyl-sn-glycero-3-dehydrophenylalanine ester structural units. The ABTS radical scavenging activity of the dorsamin-A's was comparable with or stronger than that of Trolox.