63701-56-4

Basic information

• Product Name: S(-)-BACLOFEN HCL
• Synonyms: S(-)-BACLOFEN HCL;(-)-baclofenhydrochloride;(-)-s-3-(p-chlorophenyl)-4-aminobutanoicacidhydrochloride;beta-(aminomethyl)-4-chloro-,hydrochloride,(s)-benzenepropanoicaci;beta-(aminomethyl)-p-chloro-,hydrochloride,(s)-hydrocinnamicaci;l-baclofenhydrochloride;s(-)-β-(aminomethyl)-4-chlorobenzenepropanoic acid hydrochloride;S(-)-BACLOFENHYDROCHLORIDE(FORR&DONLY)
• CAS NO: 63701-56-4
• Molecular Formula: C₁₀H₁₂ClNO₂*ClH
• Molecular Weight: 250.12172
• Mol File: 63701-56-4.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 364.3°Cat760mmHg
• Flash Point: 174.1°C
• Appearance: white/solid
• Density: g/cm³
• Vapor Pressure: 6.01E-06mmHg at 25°C
• Solubility: DMSO: >20 mg/mL
• CAS DataBase Reference: S(-)-BACLOFEN HCL(CAS DataBase Reference)
• NIST Chemistry Reference: S(-)-BACLOFEN HCL(63701-56-4)
• EPA Substance Registry System: S(-)-BACLOFEN HCL(63701-56-4)

Safety Data

• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• RTECS: MW5084400
• Hazardous Substances Data: 63701-56-4(Hazardous Substances Data)

Usage

Biochem/physiol Actions

S(?)-Baclofen hydrochloride is a less active enantiomer of baclofen.

InChI:InChI=1/C10H12ClNO2.ClH/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14;/h1-4,8H,5-6,12H2,(H,13,14);1H/t8-;/m1./s1

Upstream product

• 123632-31-5 (S)-(+)-4-(4-chlorophenyl)pyrrolidin-2-one 
• 750649-51-5 (S)-(+)-3-(4-chloro-phenyl)-4-nitro-butyric acid 
• 52927-44-3 dimethyl 2-(4-chlorobenzylidene)malonate 
• 360072-54-4 methyl 2-carbomethoxy-4-nitro-3-(4-chloro-phenyl)-butyrate 
• 89979-04-4 1-(4-chlorophenyl)-2-nitroethanol 
• 706-07-0 1-chloro-4-(2-nitrovinyl)benzene 
• 123632-35-9 (R)-(-)-4-(4-chlorophenyl)pyrrolidin-2-one 
• 1186588-18-0 C₁₃H₁₆ClNO₄ 
• 137310-14-6 trimethyl 2-(4-chlorophenyl)propane-1,1,3-tricarboxylate 
• 137310-15-7 dimethyl 3-(p-chlorophenyl)glutarate 
• 1095545-18-8 (3S)-3-(4-chlorophenyl)pyrrolidine hydrochloride 
• 171897-45-3 (3S)-1-tert-butoxycarbonyl-3-(4-chlorophenyl)pyrrolidine 
• 321575-57-9 (R)-phenyl 3-(4-chlorophenyl)-4-nitrobutanoate 
• 85142-29-6 4-nitro-1-phenyl-1-(4'-chlorophenyl)-1-butanone 

Relevant articles and documents

One-Pot Synthesis of (S)-Baclofen via Aldol Condensation of Acetaldehyde with Diphenylprolinol Silyl Ether Mediated Asymmetric Michael Reaction as a Key Step

An efficient asymmetric total synthesis of (S)-baclofen was accomplished via a one-pot operation from commercially available materials using sequential reactions, such as aldol condensation of acetaldehyde, diphenylprolinol silyl ether mediated asymmetric Michael reaction of nitromethane, Kraus-Pinnick oxidation, and Raney Ni reduction. Highly enantioenriched baclofen was obtained in one pot with a good yield over four reactions.

Stereoselective reaction of 2-carboxythioesters-1,3-dithiane with nitroalkenes: An organocatalytic strategy for the asymmetric addition of a glyoxylate anion equivalent

An efficient organocatalytic methodology has been developed to perform the stereoselective addition of 2-carboxythioesters-1,3-dithiane to nitroalkenes. Under mild reaction conditions γ-nitro-β-aryl-α-keto esters with up to 92% ee were obtained, realizing a formal catalytic stereoselective conjugate addition of the glyoxylate anion synthon. The reaction products are versatile starting materials for further synthetic transformations; for example, the simultaneous reduction of the nitro group and removal of the dithiane ring was accomplished, allowing the preparation of a GABAB receptor agonist baclofen.

Rhodium-catalyzed asymmetric addition of arylboronic acids to γ-phthalimido-substituted-α,β-unsaturated carboxylic acid esters: An approach to γ-amino acids

Efficient Rh-catalyzed asymmetric 1,4-addition of arylboronic acids to ethyl-γ-phthalimidocrotonate by using bis-sulfoxide ligand affords γ-aminobutyric acid (GABA) derivatives with high enantioselectivities (90-96% ee) under mild conditions. Optically pu