137310-15-7

Basic information

• Product Name: dimethyl 3-(p-chlorophenyl)glutarate
• Synonyms: dimethyl 3-(p-chlorophenyl)glutarate
• CAS NO: 137310-15-7
• Molecular Weight: 270.713
• Mol File: 137310-15-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: dimethyl 3-(p-chlorophenyl)glutarate(CAS DataBase Reference)
• NIST Chemistry Reference: dimethyl 3-(p-chlorophenyl)glutarate(137310-15-7)
• EPA Substance Registry System: dimethyl 3-(p-chlorophenyl)glutarate(137310-15-7)

Safety Data

• Hazardous Substances Data: 137310-15-7(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 35271-74-0 3-(4-chlorophenyl)pentane-1,5-dioic acid 
• 20754-21-6 methyl 3-(4-chlorophenyl)propenoate 
• 1615-02-7 3-(4-chlorophenyl)prop-2-enoic acid 
• 137310-14-6 trimethyl 2-(4-chlorophenyl)propane-1,1,3-tricarboxylate 

Downstream Products

• 63701-56-4 (+)-Baclofen hydrochloride 
• 63701-55-3 (R)-(-)-baclofen hydrochloride 
• 159156-84-0 3-(p-chlorophenyl)glutaramide 
• 69308-37-8 (R)-baclofen 
• 137310-16-8 (R)-3-(4-chlorophenyl)-glutaric acid monomethyl ester 
• 865366-99-0 (S)-3-(4-chlorophenyl)-glutaric acid monomethyl ester 

Relevant articles and documents

Chemoenzymatic synthesis of both enantiomers of baclofen

Both enantiomers of baclofen have been synthesized in five steps from 4-chlorocinnamic acid. The key step is the highly stereoselective enzymatic hydrolysis of dimethyl 3-(4-chlorophenyl)glutarate by chymotrypsin.

Chirality holds the key for potent inhibition of the botulinum neurotoxin serotype a protease

(Chemical Equetion Presentation) Botulinum neurotoxin serotype A (BoNT/A) is the most toxic protein known to man and also a bioterrorism agent. As defined by our previous research targeting the etiological agent responsible for BoNT/A intoxication, a protease, we now report on the asymmetric synthesis of four new BoNT/A inhibitors; the most potent of this series is roughly 2-fold more active than the best small molecule inhibitor currently known.