63721-05-1Relevant articles and documents
A biomimetic approach to taxol: Stereoselective synthesis of a 12-membered ring ene-epoxide
Takahashi, Takashi,Okabe, Tadashi,Iwamoto, Hajime,Hirose, Yoichiro,Yamada, Haruo,Doi, Takayuki,Usui, Shuji,Fukazawa, Yoshimasa
, p. 31 - 37 (1997)
The stereoselective synthesis of a taxol intermediate via a biomimetic route is described. Aldol condensation of γ-butyrolactone and citral derivatives generated three stereogenic centers at positions C1, C2, and C11 corresponding to taxol. Intramolecular alkylation of the cyanohydrin ether efficiently formed the 12-membered ring system in which stereoselective reduction, followed by directed epoxidation, afforded the key intermediate epoxide.
POLYMERIZATION OF OLEFINS
-
, (2008/06/13)
Olefins containing selected functional groups such as silyl, ether and alkenyl, and often containing a blocking group, may be copolymerized with unsubstituted olefins such as ethylene and propylene in the presence of certain coordination compounds of nickel or palladium. The resulting polymers are useful as molding resins, elastomers, in adhesives and for films.
Process for the preparation of γ-unsaturated carboxylates
-
, (2008/06/13)
The invention concerns a process for the preparation of γ-unsaturated carboxylic acid methyl esters by reacting an allyl alcohol with an excess of trimethyl orthoacetate in the presence of an acidic catalyst. The process involves: the slow addition of the allyl alcohol to trimethyl orthoacetate heated to a temperature at or near its boiling point; removal of portion of the trimethyl orthoacetate from the reaction mixture by distillation; and heating the remaining reaction mixture at a temperature of 130° to 160° C. to complete the reaction.