63845-33-0

Basic information

• Product Name: N-CBZ-4-PIPERIDINEPROPIONIC ACID
• Synonyms: 4-(2-CARBOXY-ETHYL)-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER;N-CBZ-4-PIPERIDINEPROPIONIC ACID;1-Cbz-4-Piperidinepropionic Acid;3-(1-(benzyloxycarbonyl)piperidin-4-yl)propanoic acid;4-Piperidinepropanoic acid, 1-[(phenylmethoxy)carbonyl]-;3-(1-((Benzyloxy)
• CAS NO: 63845-33-0
• Molecular Formula: C₁₆H₂₁NO₄
• Molecular Weight: 291.34
• Product Categories: pharmacetical
• Mol File: 63845-33-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 469.871 °C at 760 mmHg
• Flash Point: 237.97 °C
• Appearance: /
• Density: 1.191 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.547
• Storage Temp.: 2-8°C
• PKA: 4.73±0.10(Predicted)
• CAS DataBase Reference: N-CBZ-4-PIPERIDINEPROPIONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: N-CBZ-4-PIPERIDINEPROPIONIC ACID(63845-33-0)
• EPA Substance Registry System: N-CBZ-4-PIPERIDINEPROPIONIC ACID(63845-33-0)

Safety Data

• Hazardous Substances Data: 63845-33-0(Hazardous Substances Data)

Usage

General Description

N-Cbz-4-piperidinepropionic acid, also known as N-Carbobenzyloxy-4-piperidinepropionic acid, is a chemical compound commonly used in organic synthesis and pharmaceutical research. It is a derivative of piperidine and propionic acid, with a benzyl group attached to the nitrogen atom of the piperidine ring. N-Cbz-4-piperidinepropionic acid is often used as a protective group in peptide and drug synthesis, as well as a precursor for various pharmaceutical agents. Its chemical structure and reactivity make it valuable in the development of bioactive molecules and drug candidates. N-Cbz-4-piperidinepropionic acid is an important building block in medicinal chemistry and drug discovery due to its versatility and potential applications in the synthesis of biologically active compounds.

InChI:InChI=1/C16H21NO4/c18-15(19)7-6-13-8-10-17(11-9-13)16(20)21-12-14-4-2-1-3-5-14/h1-5,13H,6-12H2,(H,18,19)

Upstream product

• 1822-32-8 3-(4-piperidyl)propionic acid 
• 501-53-1 benzyl chloroformate 
• 6318-43-0 3-pyridin-4-yl-propionic acid 
• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 
• 51052-79-0 3-(4-piperidinyl)propionic acid hydrochloride 
• 5337-79-1 3-(4-pyridinyl)-2-propenoic acid 
• 99197-86-1 ethyl 1-[(phenylmethoxy)carbonyl]-4-piperidinepropanoate 
• 2033-24-1 cycl-isopropylidene malonate 
• 138163-08-3 N-(benzyloxycarbonyl)piperidine-4-carboxaldehyde 

Downstream Products

• 169498-29-7 (R)-1-[3-(1-benzyloxycarbonyl-4-piperidyl)propionyl]-3-piperidinecarboxylic acid 
• 198958-88-2 [S-(R*,S*)]-β-[[[1-[1-oxo-3-(4-piperidinyl)propyl]-3-piperidinyl]carbonyl]amino]-3-pyridine propanoic acid 
• 124438-28-4 β-<1-(carbobenzoxy)-4-piperidine>propionyl chloride 
• 169496-24-6 N-(1-{3-(1-benzyloxycarbonyl-4-piperidyl)propionyl}-1,2,3,4-tetrahydro-3-quinolylcarbonyl]-β-alanine ethyl ester 

Relevant articles and documents

HYDROXYINDALPINE DERIVATIVES AND THEIR MEDICAL USE

The present invention relates to hydroxyindalpine derivatives of formula (I) as defined herein and pharmaceutical compositions comprising these compounds, as well as their medical use, particularly in the treatment or prevention of gastrointestinal diseases/disorders, such as constipation and functional dyspepsia.

4-[(4-(CARBOXYETHYL) PIPERIDINYL) METHYL] PYRROLIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

3-Substituted pyrrolidines having a 4-carboxypiperidinylmethyl substituent on the 4-position of the ring are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-3 and/or CCR-5.

Antirhinoviral heteroamine-substituted pyridazines

Novel pyridazinamines having antirhinoviral activity, compositions containing these compounds as active ingredient, and a method of inhibiting combating or preventing the growth of viruses in warm-blooded animals suffering from diseases caused by these viruses.