6422-35-1

Basic information

• Product Name: Z-GLY-GLY-NH2
• Synonyms: Z-GLYCYL-GLYCINE AMIDE;Z-GLY-GLY-NH2;Benzyl (2-((2-amino-2-oxoethyl)amino)-2-oxoethyl)carbamate
• CAS NO: 6422-35-1
• Molecular Formula: C₁₂H₁₅N₃O₄
• Molecular Weight: 265.27
• Mol File: 6422-35-1.mol
• Article Data: 7

Chemical Properties

• Melting Point: 170-172 °C
• Boiling Point: 608.4 °C at 760 mmHg
• Flash Point: 321.7 °C
• Appearance: /
• Density: 1.279 g/cm³
• Vapor Pressure: 9.56E-15mmHg at 25°C
• Refractive Index: 1.558
• Storage Temp.: -15°C
• PKA: 11.08±0.46(Predicted)
• CAS DataBase Reference: Z-GLY-GLY-NH2(CAS DataBase Reference)
• NIST Chemistry Reference: Z-GLY-GLY-NH2(6422-35-1)
• EPA Substance Registry System: Z-GLY-GLY-NH2(6422-35-1)

Safety Data

• Hazardous Substances Data: 6422-35-1(Hazardous Substances Data)

Usage

General Description

Z-GLY-GLY-NH2 is a chemical compound consisting of two glycine molecules (commonly referred to as Z-Gly-Gly) and an amino group (NH2) at one end. It is often used as a substrate in enzymatic assays and as a building block in peptide synthesis. The "Z" in the compound's name refers to the protective group used to prevent undesired reactions during the synthesis process. As a dipeptide, Z-Gly-Gly-NH2 plays a role in the formation of larger peptides and proteins, and its properties make it a valuable tool in the study of enzymatic processes and the development of new pharmaceuticals.

InChI:InChI=1/C12H15N3O4/c13-10(16)6-14-11(17)7-15-12(18)19-8-9-4-2-1-3-5-9/h1-5H,6-8H2,(H2,13,16)(H,14,17)(H,15,18)

Upstream product

• 3005-87-6 Z-Gly-Gly-OEt 
• 1138-80-3 N-(Benzyloxycarbonyl)glycine 
• 598-41-4 H-Gly-NH₂ 
• 1668-10-6 glycinamide hydrochloride 
• 2566-19-0 CbzGlyGly 
• 77280-61-6 {(2-Benzyloxycarbonylamino-acetyl)-[cyclohexylcarbamoyl-(9H-fluoren-9-yl)-methyl]-amino}-acetic acid methyl ester 
• 501-53-1 benzyl chloroformate 
• 3479-49-0 glycylglycine amide hydrobromide 

Downstream Products

• 1434589-24-8 C₂₆H₂₈N₃O₆P 
• 20238-94-2 glycylglycinamide 

Relevant articles and documents

Direct synthesis of phosphinopeptides containing C-terminal α-aminoalkylphosphinic acids

A series of phosphinopeptides containing C-terminal α- aminoalkylphosphinic acids were prepared in good yields directly in one-pot reactions of 2-(N-benzoxycarbonylamino)alkanamides/peptide amides, aldehydes, and aryldichlorophosphines, followed by hydrolysis. In the current method, the peptide bond was formed in a Mannichtype reaction. Springer-Verlag 2010.

Synthesis and biological evaluation of analogues of the antibiotic pantocin B

Strains of the bacteria Erwinia herbicola produce antibiotics that effectively control E. amylovora, the bacterial pathogen responsible for the plant disease fire blight. Pantocin B was the first of these antibiotics to be characterized, and a flexible sy

Activation of carboxylic acids by pyrocarbonates. Application of di-tert-butyl pyrocarbonate as condensing reagent in the synthesis of amides of protected amino acids and peptides

Amides formation from protected amino acids and peptides was achieved in an easy and convenient one-pot procedure using di-tert-butyl pyrocarbonate as activating agent in the presence of pyridine and ammonium hydrogencarbonate. The method gave good yields and did not induce racemization during the amidation of urethane protected amino acids.