64328-55-8

Basic information

• Product Name: 4-ETHYLBENZENE-1-CARBOHYDRAZIDE
• Synonyms: 4-ETHYLBENZHYDRAZIDE;4-ETHYLBENZENE-1-CARBOHYDRAZIDE;4-ETHYLBENZOIC ACID HYDRAZIDE;4-ethylbenzohydrazide;Benzoic acid, 4-ethyl-,hydrazide
• CAS NO: 64328-55-8
• Molecular Formula: C₉H₁₂N₂O
• Molecular Weight: 164.2
• Product Categories: Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes;Phenyls & Phenyl-Het;Phenyls & Phenyl-Het
• Mol File: 64328-55-8.mol
• Article Data: 10

Chemical Properties

• Melting Point: 84 °C
• Appearance: /
• Density: 1.096 g/cm³
• Refractive Index: 1.558
• CAS DataBase Reference: 4-ETHYLBENZENE-1-CARBOHYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ETHYLBENZENE-1-CARBOHYDRAZIDE(64328-55-8)
• EPA Substance Registry System: 4-ETHYLBENZENE-1-CARBOHYDRAZIDE(64328-55-8)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 64328-55-8(Hazardous Substances Data)

Usage

General Description

4-Ethylbenzene-1-carbohydrazide is a chemical compound, which belongs to the class of organic compounds known as hydrazides and derivatives. The hydrazides are compounds containing a hydrazide moiety, which consists of a hydrazine substituted by one or two alkyl or aryl groups, and 4-Ethylbenzene-1-carbohydrazide falls under this category with its chemical structure. Because of its chemical properties, it can be used in various applications such as pharmaceuticals and agrochemicals. As with all chemicals, it should be handled with proper safety measures. However, detailed information about its toxicity, safety, or environmental impact is not widely available as of yet.

InChI:InChI=1/C9H12N2O/c1-2-7-3-5-8(6-4-7)9(12)11-10/h3-6H,2,10H2,1H3,(H,11,12)

Upstream product

• 36207-13-3 ethyl ester of para-ethylbenzoic acid 
• 619-64-7 p-ethylbenzoic acid 
• 7364-20-7 4-ethyl-benzoic acid methyl ester 

Downstream Products

• 1155869-00-3 C₁₈H₂₈N₂O 
• 1156004-51-1 N'-(2-cyanoethyl)-4-ethylbenzohydrazide 
• 1571911-49-3 N′-(7-amino-5H-pyrrolo[3,4-b]pyrazin-5-ylidene)-4-ethylbenzohydrazide 
• 1609020-84-9 3-acetyl-5-(4-ethyl-phenyl)-2-(5-nitrofuran-2-yl)-2,3-dihydro-1,3,4-oxadiazole 
• 935559-51-6 4-ethyl-N’-((5-nitrofuran-2-yl)methylene)benzohydrazide 
• 1093131-62-4 (R)-4-ethylbenzoic acid N'-(1-phenethylbut-3-enyl)hydrazide 
• 1393841-24-1 ethyl 2,2-dimethyl-1-(2-(4-ethylbenzoyl)hydrazinecarboxamido)cyclopropanecarboxylate 
• 350672-18-3 2-chloromethyl-5-(4-ethyl-phenyl)-[1,3,4]oxadiazole 
• 863289-14-9 4-(4-amino-butyl)-5-(4-ethyl-phenyl)-4H-[1,2,4]triazole-3-thiol 
• 863289-02-5 C₁₄H₂₂N₄OS 
• 499129-04-3 4-ethyl-benzoic acid N'-chloroacetyl-hydrazide 

Relevant articles and documents

Synthesis and bioactivity of sulfide derivatives containing 1,3,4-oxadiazole and pyridine

A series of novel sulfide derivatives containing 1,3,4-oxadiazole and pyridine were synthesized, characterized, and tested for their antibacterial activity against tobacco bacterial wilt and rice bacterial blight and for insecticidal activity toward diamondback moth. The results showed that some compounds had good insecticidal and bactericidal activity, e.g., the activities of compounds 6e and 6g–6j toward tobacco bacterial wilt were much better than those of commercial thiodiazole-copper, and some of the synthesized compounds possessed good insecticidal activity against Plutella xylostella. Compounds 6d, 6h, 6j, 6l, 6p, 6r, and 6p displayed over 93% activity at 500 mg L? 1.

Design, synthesis, insecticidal activity and 3D-QSR study for novel trifluoromethyl pyridine derivatives containing an 1,3,4-oxadiazole moiety

A series of trifluoromethyl pyridine derivatives containing 1,3,4-oxadiazole moiety was designed, synthesized and bio-assayed for their insecticidal activity. The result of bio-assays indicated the synthesized compounds exhibited good insecticidal activity against Mythimna separata and Plutella xylostella, most of the title compounds show 100% insecticidal activity at 500 mg L-1 and >80% activity at 250 mg L-1 against the two pests. Compounds E18 and E27 showed LC50 values of 38.5 and 30.8 mg L-1 against Mythimna separata, respectively, which were close to that of avermectin (29.6 mg L-1); compounds E5, E6, E9, E10, E15, E25, E26, and E27 showed 100% activity at 250 mg L-1, which were better than chlorpyrifos (87%). CoMFA and CoMSIA models with good predictability were proposed, which revealed the electron-withdrawing groups with an appropriate bulk at 2- and 4-positions of benzene ring could enhance insecticidal activity.

Novel 4H-1,3,4-oxadiazin-5(6H)-ones with hydrophobic and long alkyl chains: Design, synthesis, and bioactive diversity on inhibition of monoamine oxidase, chitin biosynthesis and tumor cell

A new series of nitrogen-containing heterocycles 4H-1,3,4-oxadiazin-5(6H)-ones derivatives with hydrophobic and long chains were designed and synthesized by direct cyclization reaction of N′-alkylation substituted aroylhydrazines with chloroacetyl chloride. The preliminary assays showed that some of the compounds displayed moderate to good inhibitory activities toward monoamine oxidase (MAO) at the concentration of 10-5-10-3 M, and antitumor activities against human lung cancer A-549 and human prostate cancer PC-3 cell lines at μM level, which might provide new scaffold for anticancer agents. Furthermore, compounds 5i and 5m exhibited significant inhibitory activity on chitin biosynthesis, which might represent a novel class of highly potential inhibitors of chitin synthesis. Crown Copyright