64369-55-7Relevant articles and documents
Synthesis of novel push-pull fluorescent dyes-7-(diethylamino)furo[3,2-c]coumarin and 7-(diethylamino)thieno[3,2-c]coumarin derivatives
Akchurin, Igor O.,Yakhutina, Anna I.,Bochkov, Andrei Y.,Solovjova, Natalya P.,Traven, Valerii F.
, p. 85 - 91 (2018)
Novel push-pull fluorescent dyes, 7-(diethylamino)furo[3,2-c]coumarin and 7-(diethylamino)thieno[3,2-c]coumarin derivatives, were designed and synthesized using formyl derivatives of furo-and thieno[3,2-c]coumarins as key intermediates. Electron absorption and emission spectra of the dyes were recorded in different solvents. The longest-wave bands in the electron absorption spectra of the dyes are suggested to be of push-pull nature.
BF2 group chelated AIE fluorescent probe for polarity mapping of lipid droplets in cells and in vivo
Lai, Chaofeng,Zhao, Yuping,Liang, Yun,Zou, Xiang,Lin, Weiying
supporting information, (2021/12/02)
Lipid droplets (LDs), are multi-functional organelles with the storage of neutral lipids and proteins, participating in various of physiological processes. However, abnormal of LDs in morphology and numbers always lead to multiple diseases, including canc
Structural Features of a Family of Coumarin-Enamine Fluorescent Chemodosimeters for Ion Pairs
Davis, Aaron B.,Ihde, Michael H.,Busenlehner, Alie M.,Davis, Dana L.,Mia, Rashid,Panella, Jessica,Fronczek, Frank R.,Bonizzoni, Marco,Wallace, Karl J.
, p. 14238 - 14252 (2021/09/20)
A family of coumarin-enamine chemodosimeters is evaluated for their potential use as fluorescent molecular probes for multiple analytes [cadmium(II), cobalt(II), copper(II), iron(II), nickel(II), lead(II), and zinc(II)], as their chloride and acetate salts. These fluorophores displayed excellent optical spectroscopic modulation when exposed to ion pairs with different Lewis acidic and basic properties in dimethyl sulfoxide (DMSO). The chemodosimeters were designed to undergo excited-state intramolecular proton transfer (ESIPT), which leads to significant Stokes shifts (ca. 225 nm) and lower-energy fluorescence emission (ca. 575 nm). A more basic anion, e.g., acetate, inhibited the ESIPT mechanism by deprotonation of the enol, producing a binding pocket (N^O-chelate) that can coordinate to an appropriate metal ion. Coordination of the metal ions enhances the fluorescent intensity via the chelation-enhanced fluorescence emission mechanism. Subjecting the spectroscopic data to linear discriminant analysis provided insights into the source of these systems’ markedly different behavior toward ion pairs, despite the subtle structural differences in the organic framework. These compounds are examples of versatile, low-molecular-weight, dual-channel fluorescent sensors for ion-pair recognition. This study paves the way for using these probes as practical components of a sensing array for different metal ionsandtheir respective anions.
Thienocoumarin-based ratio-type probe and preparation and application thereof
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Paragraph 0045-0048, (2021/11/10)
The invention belongs to the field of fluorescence analysis and biological small molecule detection, and discloses a thienocoumarin-based ratio-type probe and preparation and application thereof. The structure of the probe is shown in the specification. The preparation method of the thienocoumarin-based fluorescent probe CSN is simple, the fluorescent probe has very strong fluorescence response to hypochlorite ions, and the fluorescence intensity at the fluorescence wavelengths of 470 nm and 640 nm is in ratio type change. The fluorescent probe CSN can be directly applied to rapid detection and biological imaging of hypochlorite ions in an aqueous solution and a cell environment.