64436-58-4

Basic information

• Product Name: 1-Propanone, 2-methyl-1-[4-(trifluoromethyl)phenyl]-
• CAS NO: 64436-58-4
• Molecular Formula: C11H11F3O
• Molecular Weight: 216.203
• Mol File: 64436-58-4.mol
• Article Data: 18

Chemical Properties

• CAS DataBase Reference: 1-Propanone, 2-methyl-1-[4-(trifluoromethyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanone, 2-methyl-1-[4-(trifluoromethyl)phenyl]-(64436-58-4)
• EPA Substance Registry System: 1-Propanone, 2-methyl-1-[4-(trifluoromethyl)phenyl]-(64436-58-4)

Safety Data

• Hazardous Substances Data: 64436-58-4(Hazardous Substances Data)

Usage

Appearance

Yellow to yellow-green liquid

Odor

Strong, aromatic

Usage

Intermediate in the synthesis of pharmaceuticals and agrochemicals, solvent for organic reactions, reagent in organic synthesis, potential precursor to other fluorinated compounds

Importance

Versatile reactivity, functional groups, and as a building block in the chemical industry

Precautions

Handle with care and in accordance with proper safety measures due to reactivity and potential health hazards.

Upstream product

• 1068-55-9 isopropylmagnesium chloride 
• 329-15-7 4-trifluoromethyl-phenyl acetyl chloride 
• 116332-61-7 N-methoxy-N-methyl-4-trifluoromethylbenzamide 
• 709-63-7 1-(4-trifluoromethylphenyl)ethanone 
• 74-88-4 methyl iodide 
• 455-24-3 4-trifluoromethylbenzoic acid 
• 67-56-1 methanol 
• 149946-79-2 1-(4'-(trifluoromethyl)phenyl)-allylalcohol 
• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 2403-57-8 1-(2-methylprop-1-en-1-yl)pyrrolidine 
• 1301645-90-8 N-isopropyl-4-(trifluoromethyl)benzamide 
• 711-33-1 4-trifluoromethyl propiophenone 
• 455-18-5 4-CF₃C₆H₄CN 
• 920-39-8 isopropylmagnesium bromide 

Downstream Products

• 1069130-35-3 C₁₉H₁₄F₃NO₃ 
• 1069130-28-4 C₁₉H₁₅F₃O 
• 359803-67-1 4-(trifluoromethyl)benzoic acid butyl ester 
• 1364858-50-3 C₁₂H₁₅F₃ 
• 1364859-38-0 C₁₂H₁₅F₃ 
• 1364857-92-0 C₁₂H₁₃F₃ 
• 197508-91-1 2-methyl-1-(4-(trifluoromethyl)phenyl)propan-1-ol 
• 1355254-06-6 C₁₅H₂₁F₃OSi 

Relevant articles and documents

C-C coupling of ketones with methanol catalyzed by a N-heterocyclic carbene-phosphine iridium complex

An N-heterocyclic carbene-phosphine iridium complex system was found to be a very efficient catalyst for the methylation of ketone via a hydrogen transfer reaction. Mild conditions together with low catalyst loading (1 mol%) were used for a tandem process which involves the dehydrogenation of methanol, C=C bond formation with a ketone, and hydrogenation of the new generated double bond by iridium hydride to give the alkylated product. Using this iridium catalyst system, a number of branched ketones were synthesized with good to excellent conversions and yields.

External-oxidant-free amino-benzoyloxylation of unactivated alkenes of unsaturated ketoximes with: O -benzoylhydroxylamines

A new copper-catalyzed two-component amino-benzoyloxylation of unactivated alkenes of unsaturated ketoximes with O-benzoylhydroxylamines as the benzoyloxy sources is developed. Chemoselectivity of this method toward amino-benzoyloxylation or oxy-benzoyloxylation of alkenyl ketoximes relies on the position of the tethered olefins, and provides an external-oxidant-free alkene difunctionalization route that directly utilizes O-benzoylhydroxylamines as the benzoyloxy radical precursors and internal oxidants for the divergent synthesis of cyclic nitrones and isoxazolines.

Silver-promoted cascade radical cyclization of γ,δ-unsaturated oxime esters with P(O)H compounds: synthesis of phosphorylated pyrrolines

A cascade radical cyclization was realized for the first silver-promoted imino-phosphorylation of γ,δ-unsaturated oxime esters, which provided a step-economical and redox-neutral route to access a variety of phosphorylated pyrrolines in good to excellent yields. Moreover, a new bulky trivalent phosphine ligand with a pyrroline motif was obtained through a deoxidation process.