646522-74-9

Basic information

• Product Name: Methanesulfonic acid, trifluoro-, 2-(1-oxopropyl)phenyl ester
• CAS NO: 646522-74-9
• Molecular Formula: C10H9F3O4S
• Molecular Weight: 282.24
• Mol File: 646522-74-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Methanesulfonic acid, trifluoro-, 2-(1-oxopropyl)phenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Methanesulfonic acid, trifluoro-, 2-(1-oxopropyl)phenyl ester(646522-74-9)
• EPA Substance Registry System: Methanesulfonic acid, trifluoro-, 2-(1-oxopropyl)phenyl ester(646522-74-9)

Safety Data

• Hazardous Substances Data: 646522-74-9(Hazardous Substances Data)

Upstream product

• 358-23-6 trifluoromethylsulfonic anhydride 
• 610-99-1 1-(2-Hydroxy-phenyl)-propan-1-on 

Downstream Products

• 35567-59-0 2-methyl benzofuran-3(2H)-one 
• 4855-02-1 benzyl trifluoromethyl sulfone 
• 93-54-9 1-Phenyl-1-propanol 
• 93-55-0 1-phenyl-propan-1-one 
• 646522-85-2 trifluoromethanesulfonic acid 1-(2-hydroxyphenyl)propenyl ester 

Relevant articles and documents

One-pot synthesis of 4-methylisoquinolines via a sequential Pd-catalyzed Heck reaction and intramolecular cyclization

An efficient, one-pot synthesis of 4-methylisoquinolines via a cascade Pd-catalyzed Heck reaction, intramolecular cyclization and isomerization has been developed. This reaction has a wide range of substrates with various functional groups, and the corresponding products have been obtained in good yields.

Unexpected Migration and Oxidative Cyclization of Substituted 2-Acetophenone Triflates under Basic Conditions: Synthetic and Mechanistic Insights

Oxidative ring closure of alkyl-substituted 2-hydroxyacetophenone trifluoromethanesulfonate esters (triflates) occurs upon exposure to base in anaerobic DMF at 20-90 °C. Alkyl substitution is required for ring closure. A migrated enol triflate product forms at lower temperature in high yield via migration of the trifluoromethanesulfonate in the unsubstituted and monoalkyl-substituted cases. The alkyl-substituted enol triflates also enter into the benzofuran-3-one ring-forming process under thermal cyclization conditions. Potential mechanistic pathways are evaluated.