647852-02-6Relevant articles and documents
A practical diastereoselective synthesis of β-amino-α-hydroxy carboxylates
Lee, Jae-Mok,Lim, Hyun-Suk,Seo, Kyung-Chang,Chung, Sung-Kee
, p. 3639 - 3641 (2007/10/03)
Practical synthetic routes to β-amino-α-hydroxy carboxylates (AHC) have been developed from amino acids. Reduction of β-amino-α- keto esters 6 with NaBH4 was found to give anti-AHCs 7 in high de, which were efficiently converted to the corresponding syn-AHCs 8 via oxazolidine ring 10 formation.