6591-61-3

Basic information

• Product Name: Methyl a-Phenylglycinate
• Synonyms: Methyl a-Phenylglycinate
• CAS NO: 6591-61-3
• Molecular Formula: C9H11NO2
• Molecular Weight: 165.192
• Mol File: 6591-61-3.mol
• Article Data: 82

Chemical Properties

• Boiling Point: 139 °C (10 mmHg)
• CAS DataBase Reference: Methyl a-Phenylglycinate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl a-Phenylglycinate(6591-61-3)
• EPA Substance Registry System: Methyl a-Phenylglycinate(6591-61-3)

Safety Data

• Hazardous Substances Data: 6591-61-3(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 39478-47-2 amino-phenyl-acetyl chloride 
• 169512-94-1 (+/-)-N-tert-butoxycarbonyl-α-phenylglycine methyl ester 
• 952524-02-6 (S)-1-benzoyl-2-(α-acetoxyethyl)benzimidazole 
• 24461-61-8 phenylglycine methyl ester 
• 15028-39-4 L-2-phenylglycine methyl ester hydrochloride 
• 51335-08-1 (4-methoxy-phenylimino)-phenyl-acetic acid methyl ester 
• 1360149-22-9 methyl (S)-2-(1,1-dimethylethylsulfonamido)-2-phenylacetate 
• 15206-55-0 methyl 2-oxo-2-phenylacetate 
• 147780-61-8 (S)-methyl 2-(benzyloxycarbonylamino)-2-phenylacetate 
• 22979-35-7 Methyl phenyldiazoacetate 
• 1360863-29-1 methyl (Z)-2-(benzyloxycarbonylimino)-2-phenylacetate 
• 15028-40-7 DL-2-phenylglycine methyl ester hydrochloride 
• 186581-53-3 diazomethane 

Downstream Products

• 134810-89-2 methyl 3-(2-acetamidophenyl)propanoate 
• 78907-06-9 N-benzyl-2-phenylglycine methyl ester 
• 63430-99-9 methyl N-4'-methoxybenzylidenephenylglycinate 
• 62030-12-0 (4-chloro-benzoylamino)-phenyl-acetic acid but-2t-enyl ester 
• 62030-09-5 (4-chloro-benzoylamino)-phenyl-acetic acid (Z)-3-methyl-pent-2-en-4-ynyl ester 
• 62030-10-8 (4-Chloro-benzoylamino)-phenyl-acetic acid (E)-penta-2,4-dienyl ester 
• 72129-71-6 [3-(Methoxycarbonyl-phenyl-methyl)-ureido]-phenyl-acetic acid methyl ester 
• 22979-35-7 Methyl phenyldiazoacetate 
• 120566-65-6 -4-<<(Methoxycarbonyl)phenylmethyl>amino>-4-oxo-2-butenoic acid 
• 118972-01-3 methyl (1RS,2RS,4RS,5RS)-4-phenyl-7-methyl-2-thia-6,8-dioxo-3,7-diazabicyclo<3.3.0>octane-4-carboxylate S-oxide 
• 118972-01-3 methyl (1RS,2RS,4SR,5RS)-4-phenyl-7-methyl-2-thia-6,8-dioxo-3,7-diazabicyclo<3.3.0>octane-4-carboxylate S-oxide 
• 129704-13-8 (S)-2-amino-1,1,2-triphenylethanol 
• 728-49-4 methyl 2-[N-(1,3-dioxobutyl)amino]phenylacetate 
• 875-74-1 D-(-)-α-aminophenylacetic acid 

Relevant articles and documents

Iridium-Catalyzed Amidation of in Situ Prepared Silyl Ketene Acetals to Access α-Amino Esters

Disclosed herein is a convenient Ir-catalyzed amidation of esters to access α-amido esters. Initially prepared silyl ketene acetals are directly employed, without separate purification, for subsequent amidation with an oxycarbonylnitrenoid precursor using the Cp*(LX)Ir(III) catalyst. The α-amidation was facile for both α-aryl and α-alkyl esters. Density functional theory studies revealed that the generation of a putative Ir-nitrenoid is facilitated by the chelation of the countercation additive during the N-O bond cleavage of the nitrene precursor.

Preparation method of oxazolidinone compound

The preparation method comprises the following steps 1): dissolving aromatic amino acid in methanol, dissolving the aromatic amino acid in methanol, heating up to 50 - 60 °C heat preservation 1 - 2h, 2) reducing: adding a catalytic amount of lithium salt in ethanol water as a solvent. 3) Ring-closing: toluene is used as a solvent, a reduction product and diethyl carbonate are added to 100 °C, a sodium methoxide solution is added dropwise, and the product is obtained after completion of the dropwise addition and after-treatment and purification after completion of the normal pressure distillation to the temperature of 100 °C heat preservation. The lithium salt is introduced to participate in the reaction, sodium borohydride is selected as a solvent, sodium borohydride is completely dissolved, and the lithium salt can be free from the compound to improve the reaction activity, so that the use amount of sodium borohydride is reduced to 2 equivalent, and the production cost is remarkably reduced.

A Structure?Activity Relationship Study of Novel Hydroxamic Acid Inhibitors around the S1 Subsite of Human Aminopeptidase N

Aminopeptidase N (APN/CD13) is a zinc-dependent ubiquitous transmembrane ectoenzyme that is widely present in different types of cells. APN is one of the most extensively studied metalloaminopeptidases as an anti-cancer target due to its significant role in the regulation of metastasis and angiogenesis. Previously, we identified a potent and selective APN inhibitor, N-(2-(Hydroxyamino)-2-oxo-1-(3′,4′,5′-trifluoro-[1,1′-biphenyl]-4-yl)ethyl)-4-(methylsulfonamido)benzamide (3). Herein, we report the further modifications performed to explore SAR around the S1 subsite of APN and to improve the physicochemical properties. A series of hydroxamic acid analogues were synthesised, and the pharmacological activities were evaluated in vitro. N-(1-(3′-Fluoro-[1,1′-biphenyl]-4-yl)-2-(hydroxyamino)-2-oxoethyl)-4-(methylsulfonamido)benzamide (6 f) was found to display an extremely potent inhibitory activity in the sub-nanomolar range.