6499-41-8

Basic information

• Product Name: Tetrazolo[1,5-c]quinazoline, 5-phenyl-
• CAS NO: 6499-41-8
• Molecular Formula: C14H9N5
• Molecular Weight: 247.259
• Mol File: 6499-41-8.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Tetrazolo[1,5-c]quinazoline, 5-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Tetrazolo[1,5-c]quinazoline, 5-phenyl-(6499-41-8)
• EPA Substance Registry System: Tetrazolo[1,5-c]quinazoline, 5-phenyl-(6499-41-8)

Safety Data

• Hazardous Substances Data: 6499-41-8(Hazardous Substances Data)

Upstream product

• 6484-25-9 4-chloro-2-phenylquinazoline 
• 73096-42-1 5-(2-bromophenyl)-1H-tetrazole 
• 100-52-7 benzaldehyde 
• 6484-29-3 C₁₄H₁₂N₄ 
• 6483-99-4 2-phenyl-3,4-dihydroquinazolin-4-thione 
• 1022-45-3 2-phenyl-4(3H)-quinazolinone 
• 121998-76-3 2-phenyl-2,3-dihydro-4(1H)-quinazolinone 
• 28144-70-9 anthranilic acid amide 
• 100422-74-0 ethyl 5-oxo-2-(2-phenylquinazolin-4-yl)-2,5-dihydroisoxazole-4-carboxylate 

Downstream Products

• 1286712-92-2 C₁₄H₉N₃ 
• 1286712-89-7 C₁₄H₉N₃ 
• 74144-29-9 C₁₄H₉N₃ 
• 55810-22-5 2-phenyl-1H-benzo[d]imidazole-1-carbonitrile 
• 1022-44-2 4-amino-2-phenyl-quinazoline 

Relevant articles and documents

Effect of intramolecular hydrogen bond on the azide-tetrazole equilibrium of 5-(2'-hydroxyphenyl)tetrazolopyrimidine, -tetrazolopyrimidine, -tetrazoloquinazoline and 7-(2'-hydroxyphenyl)tetrazolopyrimidine

The intramolecular hydrogen bond between the phenolic hydroxyl and the pyrimidine nitrogen atom in the title compounds exerts a destabilizing effect on the tetrazole ring and shifts the azide-tetrazole equilibrium toward the azide form, especially in the

Synthesis and anticonvulsant activity evaluation of 5-Phenyl-[1,2,4] triazolo[4,3-c]quinazolin-3-amines

In the present study we describe the syntheses and anticonvulsant activity evaluation of 5-phenyl-[1,2,4]triazolo[4,3-c]quinazolin-3-amine derivatives. Their anticonvulsant activity and neurotoxicity were evaluated by the maximal electroshock seizure test (MES) and the rotarod test, respectively. The majority of the compounds prepared were effective in the MES screens at a dose level of 100 mg/kg. Of these compounds, the most promising was compound 8h, which showed an ED50 value of 27.4 mg/kg and a protective index (PI) value of 5.8. These values were superior to those provided by valproate (ED50 and PI values of 272 and 1.6, respectively) in the MES test in mice. As well as its anti-MES efficacy, the potencies of compound 8h against seizures induced by pentylenetetrazole and thiosemicarbazide were also established, with the results suggesting that the GABAergic system-mediated mechanisms might be involved in its anticonvulsant activity. Copyright

SYNTHESIS OF SOME NEW CHLORO DERIVATIVES OF QUINAZOLINOQUINAZOLIN-8-ONE AND s-TETRAZOLOQUINAZOLINE WITH EXPECTED ANTIFUNGICIDAL AND ANTIBACTERIAL ACTIVITIES

Some derivatives of 4-chloro-2-(phenyl or 4-chlorophenyl)-1,3-quinazoline have been prepared by treating the respective 4(3H) quinazolinone derivatives with POCl3/PCl5.The products were allowed to react with anthranilic, 5-chloro and 3,5-dichloroanthranil