65126-85-4

Basic information

• Product Name: 3-(3-(trifluoroMethyl)phenyl)prop-2-yn-1-ol
• Synonyms: 3-(3-(trifluoroMethyl)phenyl)prop-2-yn-1-ol
• CAS NO: 65126-85-4
• Molecular Formula: C₁₀H₇F₃O
• Molecular Weight: 200.1571896
• Mol File: 65126-85-4.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(3-(trifluoroMethyl)phenyl)prop-2-yn-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3-(trifluoroMethyl)phenyl)prop-2-yn-1-ol(65126-85-4)
• EPA Substance Registry System: 3-(3-(trifluoroMethyl)phenyl)prop-2-yn-1-ol(65126-85-4)

Safety Data

• Hazardous Substances Data: 65126-85-4(Hazardous Substances Data)

Usage

Description

3-(3-(trifluoromethyl)phenyl)prop-2-yn-1-ol is a chemical compound with the molecular formula C10H7F3O. It is a derivative of phenylpropynol, with a trifluoromethyl group attached to the phenyl ring. 3-(3-(trifluoroMethyl)phenyl)prop-2-yn-1-ol is commonly used in organic synthesis and pharmaceutical research as a building block for the preparation of various bioactive molecules. The trifluoromethyl group contributes to the compound's unique properties and reactivity, making it a valuable intermediate in the production of diverse chemical compounds.

Uses

Used in Pharmaceutical Research:
3-(3-(trifluoroMethyl)phenyl)prop-2-yn-1-ol is used as a building block for the preparation of various bioactive molecules. Its unique properties and reactivity make it a valuable intermediate in the production of diverse chemical compounds.
Used in Organic Synthesis:
3-(3-(trifluoroMethyl)phenyl)prop-2-yn-1-ol is used as a key intermediate in the synthesis of complex organic molecules, contributing to the development of new chemical entities.
Used in Agrochemical Industry:
3-(3-(trifluoroMethyl)phenyl)prop-2-yn-1-ol may have potential applications in the agrochemical industry, where its unique properties can be utilized for the development of novel agrochemicals.
Used in Material Science Industry:
3-(3-(trifluoroMethyl)phenyl)prop-2-yn-1-ol may also have potential applications in the material science industry, where its unique properties can be employed for the development of new materials with specific characteristics.

Upstream product

• 401-78-5 3-bromo-1-trifluoromethylbenzene 
• 107-19-7 propargyl alcohol 
• 401-81-0 m-trifluoromethylphenyl iodide 
• 50-00-0 formaldehyd 
• 705-28-2 1-ethynyl-3-trifluoromethylbenzene 

Downstream Products

• 1093944-39-8 1-(3-Methanesulfonyloxy-prop-1-inyl)-3-trifluoromethyl-benzene 
• 78573-45-2 3-[3-(trifluoromethyl)phenyl]propan-1-ol 
• 1453164-34-5 1-(3-azidoprop-1-yn-1-yl)-3-(trifluoromethyl)benzene 
• 1188541-66-3 1-propyl-8-{1-[3-(3-trifluoromethylphenyl)prop-2-ynyl]-1H-pyrazol-4-yl}-3,7-dihydropurine-2, 6-dione 
• 1188540-86-4 8-{1-[3-(3-trifluoromethylphenyl)prop-2-ynyl]-1H-pyrazol-4-yl}-1,3-dipropyl-3,7-dihydropurine-2,6-dione 
• 364782-34-3 cinacalcet hydrochloride 
• 21172-41-8 3-[3-(trifluoromethyl)phenyl]propanal 
• 226256-56-0 cinacalcet 
• 1122474-47-8 (S)-5-(3-(trifluoromethyl)benzyl)-3-isopropyl-4-tosyl-3,4-dihydro-2H-1,4-oxazine 

Relevant articles and documents

Synthesis of Azepino[1,2-a]indole-10-amines via [6+1] Annulation of Ynenitriles with Reformatsky Reagent

Lewis acid-catalyzed [6+1] annulation reactions of 2-cyano-1-propargyl- and 2-alkynyl-1-cyanomethyl-indoles with Reformatsky reagent are described. 8-Aryl, 8-alkyl-, 8-hetaryl-, 9-aryl, and 9-alkyl-azepino[1,2-a]indole amines were obtained through a 7-endo-mode cyclization of the β-aminoacrylate intermediates. The antiproliferative activity of the azepino[1,2-a]indoles analogs against the HCT-116 cells were also examined.

Development of a telescoped flow process for the safe and effective generation of propargylic amines

Propargylic amines are important multifunctional building blocks that are frequently exploited in the synthesis of privileged heterocyclic entities. Herein we report on a novel flow process that achieves the safe and effective on-demand synthesis of propargylic amines in a telescoped manner. This process minimizes exposure to hazardous azide intermediates and renders a streamlined route into these building blocks. The value of this approach is demonstrated by the rapid generation of a small selection of drug-like thiazolines that result from a high-yielding reaction cascade between propargylic amines with different aryl isothiocyanates.

Metal-free aminothiation of alkynes: Three-component tandem annulation toward indolizine thiones from 2-alkylpyridines, ynals, and elemental sulfur

A metal-free three-component annulation reaction for the synthesis of indolizine thiones via tandem C-C/C-N/C-S bond formation was developed. Various 2-alkylpyridines with aromatic ynals and elemental sulfur proceeded smoothly under catalyst-free conditions, and the desired products were obtained in moderate to excellent yields.