705-28-2 Usage
Description
3-Ethynyl-α,α,α-trifluorotoluene, also known as 3-(TRIFLUOROMETHYL)PHENYLACETYLENE, is a chemical compound that features a trifluoromethyl group attached to a toluene ring with an ethynyl (acetylene) functional group. 3-ETHYNYL-ALPHA ALPHA ALPHA-TRIFLUORO& is known for its unique properties and reactivity, making it a valuable research chemical.
Uses
Used in Research and Development:
3-Ethynyl-α,α,α-trifluorotoluene is used as a research chemical for the synthesis of various complex organic molecules and pharmaceutical intermediates. Its unique structure allows for a wide range of chemical reactions and modifications, making it a versatile building block in organic chemistry.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3-Ethynyl-α,α,α-trifluorotoluene is used as a key intermediate in the synthesis of several drug candidates. Its reactivity and structural features enable the development of novel therapeutic agents with potential applications in various medical fields.
Specific Applications:
1. Synthesis of 1-thioacetyl-4[3-trifluoromethyl-1-(ethynyl)phenyl]benzene:
3-Ethynyl-α,α,α-trifluorotoluene is used as a starting material for the synthesis of 1-thioacetyl-4[3-trifluoromethyl-1-(ethynyl)phenyl]benzene, a compound with potential applications in medicinal chemistry.
2. Synthesis of 4-[4-(3-(trifluoromethyl)phenyl)-1H-1,2,3-triazol-1-yl]methylbenzoic acid:
3-ETHYNYL-ALPHA ALPHA ALPHA-TRIFLUORO& is utilized in the synthesis of 4-[4-(3-(trifluoromethyl)phenyl)-1H-1,2,3-triazol-1-yl]methylbenzoic acid, which may have potential applications in drug development.
3. Synthesis of 4-4-[3-(trifluoromethyl)phenyl]-1H-1,2,3-triazol-1-ylbenzoic acid:
3-Ethynyl-α,α,α-trifluorotoluene is also used in the synthesis of 4-4-[3-(trifluoromethyl)phenyl]-1H-1,2,3-triazol-1-ylbenzoic acid, another compound with potential pharmaceutical applications.
Check Digit Verification of cas no
The CAS Registry Mumber 705-28-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 7,0 and 5 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 705-28:
(5*7)+(4*0)+(3*5)+(2*2)+(1*8)=62
62 % 10 = 2
So 705-28-2 is a valid CAS Registry Number.
InChI:InChI=1/C9H5F3/c1-2-7-4-3-5-8(6-7)9(10,11)12/h1,3-6H
705-28-2Relevant articles and documents
Cobalt-Catalyzed Hydroalkynylation of Vinylaziridines
Biletskyi, Bohdan,Kong, Lingyu,Tenaglia, Alphonse,Clavier, Hervé
supporting information, p. 2578 - 2585 (2021/03/18)
Transition metal-catalyzed hydroalkynylation reactions are efficient transformations allowing the straightforward formation of functionalized alkynes. Therein, we disclose the cobalt-catalyzed hydroalkynylation of vinylaziridines giving rise to both linea
Regioselective Gold-Catalyzed Hydration of CF3- and SF5-alkynes
Cloutier, Mélissa,Roudias, Majdouline,Paquin, Jean-Fran?ois
supporting information, p. 3866 - 3870 (2019/05/24)
The regioselective gold-catalyzed hydration of CF3- and SF5-alkynes is described. The corresponding trifluoromethylated and pentasulfanylated ketones are obtained in up to 91% yield as single regioisomers showcasing the use of CF3 and SF5 as highly efficient directing groups in this reaction. Notably, this transformation represents the first use of CF3- and SF5-alkynes in gold catalysis.
Reaction discovery using acetylene gas as the chemical feedstock accelerated by the stop-flow micro-tubing reactor system
Xue, Fei,Deng, Hongping,Xue, Chengwen,Mohamed, Dara Khairunnisa Binte,Tang, Karen Yuanting,Wu, Jie
, p. 3623 - 3627 (2017/07/11)
Acetylene gas has been applied as a feedstock under transition-metal catalysis and photo-redox conditions to produce important chemicals including terminal alkynes, fulvenes, and fluorinated styrene compounds. The reaction discovery process was accelerated through the use of stop-flow micro-tubing reactors. This reactor prototype was developed by joining elements from both continuous micro-flow and conventional batch reactors, which was convenient and effective for gas/liquid reaction screening. Notably, the developed transformations were either inefficient or unsuccessful in conventional batch reactors. Its success relies on the unique advantages provided by this stop-flow micro-tubing reactor system.