651311-40-9Relevant articles and documents
Hydro-de-halogenation and consecutive deprotection of chlorinated N-amido-pyrrolidin-2-ones with Raney-Ni: An effective approach to gabapentin
Cagnoli, Rita,Ghelfi, Franco,Pagnoni, Ugo M.,Parsons, Andrew F.,Schenetti, Luisa
, p. 9951 - 9960 (2007/10/03)
The benzoylamino group was identified as a useful radical cyclization auxiliary that can be smoothly removed on hydro-de-halogenation of chlorinated N-substituted-pyrrolidin-2-ones with Raney-Ni. This methodology was successfully implemented in a new and appealing route to the anti-epileptic drug gabapentin.