65185-41-3

Basic information

• Product Name: 6-BROMO-QUINOLINE-2-CARBONITRILE
• Synonyms: 6-BROMO-QUINOLINE-2-CARBONITRILE;6-BROMO-2-CYANOQUINOLINE;6-BroMoquinaldonitrile;2-Quinolinecarbonitrile, 6-bromo-
• CAS NO: 65185-41-3
• Molecular Formula: C₁₀H₅BrN₂
• Molecular Weight: 233.06
• Mol File: 65185-41-3.mol
• Article Data: 11

Chemical Properties

• Melting Point: 222℃
• Boiling Point: 379.7 °C at 760 mmHg
• Flash Point: 183.5 °C
• Appearance: /
• Density: 1.66 g/cm³
• Vapor Pressure: 5.73E-06mmHg at 25°C
• Refractive Index: 1.702
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -1.45±0.43(Predicted)
• CAS DataBase Reference: 6-BROMO-QUINOLINE-2-CARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BROMO-QUINOLINE-2-CARBONITRILE(65185-41-3)
• EPA Substance Registry System: 6-BROMO-QUINOLINE-2-CARBONITRILE(65185-41-3)

Safety Data

• Hazardous Substances Data: 65185-41-3(Hazardous Substances Data)

Usage

General Description

6-Bromo-quinoline-2-carbonitrile is a specialized chemical compound, known for its molecular formula C10H5BrN2. This organic compound belongs to the class of compounds known as quinolines, which consist of a benzene ring fused to a pyridine ring. The distinguishing feature of this chemical is that one of the hydrogen atoms in the quinoline structure is replaced by a bromine atom, and there is addition of a carbonitrile group. It has considerable potential application in various areas of chemistry due to its utility as a building block in the synthesis of more complex molecules. The properties of this chemical substance such as molecular weight, density, boiling point, melting point and flash point can be determined through various laboratory methods. It should be handled with care as it may pose some risks and hazards in handling and storage.

InChI:InChI=1/C10H5BrN2/c11-8-2-4-10-7(5-8)1-3-9(6-12)13-10/h1-5H

Upstream product

• 877-42-9 6-Bromo-2-methyl-quinoline 
• 6563-11-7 6-bromoquinoline-N-oxide 
• 7677-24-9 trimethylsilyl cyanide 
• 773837-37-9 sodium cyanide 
• 5332-25-2 6-bromoquinoline 

Downstream Products

• 65148-09-6 6-bromoquinoline-2-carboxamide 
• 1381787-07-0 C₂₆H₂₄FNO₃S 
• 1381787-06-9 C₁₉H₁₈FNO 
• 1381787-05-8 C₁₉H₁₆FNO 
• 1381786-56-6 6-(4-Fluorophenyl)-2-(2-methyl-1-(1H-1,2,3-triazol-1-yl)propyl)quinoline 
• 1312609-35-0 C₃₉H₄₃N₇O₆ 
• 1312611-86-1 C₃₂H₃₂N₆O₃ 
• 1312611-36-1 C₃₇H₄₀N₆O₅ 
• 1312611-34-9 C₃₇H₄₀N₆O₆ 
• 1312609-37-2 C₄₀H₃₈N₆O₄ 
• 1312609-41-8 C₃₈H₄₂N₈O₆ 
• 1312611-26-9 C₃₈H₄₂N₈O₇ 
• 1312609-34-9 C₃₈H₄₂N₈O₆ 
• 1312611-25-8 C₃₁H₃₁N₇O₃ 

Relevant articles and documents

Quinoline-Flanked Diketopyrrolopyrrole Copolymers Breaking through Electron Mobility over 6 cm2 V?1 s?1 in Flexible Thin Film Devices

Herein, the design and synthesis of novel π-extended quinoline-flanked diketopyrrolopyrrole (DPP) [abbreviated as QDPP] motifs and corresponding copolymers named PQDPP-T and PQDPP-2FT for high performing n-type organic field-effect transistors (OFETs) in flexible organic thin film devices are reported. Serving as DPP-flankers in backbones, quinoline is found to effectively tune copolymer optoelectric properties. Compared with TDPP and pyridine-flanked DPP (PyDPP) analogs, widened bandgaps and strengthened electron deficiency are achieved. Moreover, both hole and electron mobility are improved two orders of magnitude compared to those of PyDPP analogs (PPyDPP-T and PPyDPP-2FT). Notably, featuring an all-acceptor-incorporated backbone, PQDPP-2FT exhibits electron mobility of 6.04 cm2 V?1 s?1, among the highest value in OFETs fabricated on flexible substrates to date. Moreover, due to the widened bandgap and strengthened electron deficiency of PQDPP, n-channel on/off ratio over 105 with suppressed hole transport is first realized in the ambipolar DPP-based copolymers.

Synthesis method of 2-cyanoquinoline derivative

The invention discloses a synthesis method of a 2-cyanoquinoline derivative, and belongs to the technical field of synthesis methods of chinoline and derivatives thereof. The synthesis method includes: adopting a compound represented as in formula (I) and trimethylsilyl cyanide as raw materials, dissolving the raw materials in an organic solvent, catalyzing with H-diethyl phosphite and carbon tetrachloride, and adopting alkali as a deacid reagent to prepare a compound represented as in formula (II). The synthesis method of the 2-cyanoquinoline derivative has the advantages that the adopted catalysts are low in cost and easy to obtain, the raw materials are easy to store, reaction conditions are mild, experimental operations are simple, the obtained 2-cyanoquinoline derivative products are easy to purify, high yield and applicability to industrial production are realized, and a novel synthesis method for preparing the 2-cyanoquinoline derivative is provided.

COMPOSITIONS FOR THE TREATMENT OF BRAIN TUMORS

The instant invention describes pharmaceutical compositions and dosing regimens comprising seviteronel and/or dexamethasone, and methods of treating diseases, disorders symptoms thereof.