653-31-6

Basic information

• Product Name: 2-(PENTAFLUOROPHENYL)ETHANOL
• Synonyms: Benzeneethanol, 2,3,4,5,6-pentafluoro-;2-(PENTAFLUOROPHENYL)ETHANOL;2,3,4,5,6-pentafluorophenethyl alcohol;2,3,4,5,6-Pentafluorobenzeneethanol;2-(2,3,4,5,6-pentafluorophenyl)ethanol
• CAS NO: 653-31-6
• Molecular Formula: C₈H₅F₅O
• Molecular Weight: 212.12
• EINECS: 211-499-1
• Mol File: 653-31-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 89-90°C 6mm
• Flash Point: 68.2°C
• Appearance: /
• Density: 1,525 g/cm3
• Vapor Pressure: 0.368mmHg at 25°C
• Refractive Index: 1.442
• Storage Temp.: 2-8°C
• PKA: 14.36±0.10(Predicted)
• CAS DataBase Reference: 2-(PENTAFLUOROPHENYL)ETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(PENTAFLUOROPHENYL)ETHANOL(653-31-6)
• EPA Substance Registry System: 2-(PENTAFLUOROPHENYL)ETHANOL(653-31-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 653-31-6(Hazardous Substances Data)

Usage

General Description

2-(Pentafluorophenyl)ethanol, also known as pentafluorophenylethanol, is a chemical compound with the molecular formula C8H5F5O. It is a colorless liquid with a faint sweet odor and is used in various chemical and pharmaceutical applications. 2-(PENTAFLUOROPHENYL)ETHANOL is a fluorinated analogue of phenylethanol, and its pentafluorophenyl group makes it highly valuable in organic chemistry for its ability to influence the reactivity and stability of molecules. It is also used as a building block for the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. Additionally, 2-(pentafluorophenyl)ethanol is used as a solvent and intermediate in the manufacturing process of other organic compounds. Due to its unique properties and versatility, this chemical compound plays a significant role in various industries.

InChI:InChI=1/C8H5F5O/c9-4-3(1-2-14)5(10)7(12)8(13)6(4)11/h14H,1-2H2

Upstream product

• 784-35-0 ethyl pentafluorophenylacetate 
• 653-21-4 2,3,4,5,6-pentafluorophenylacetic acid 
• 653-34-9 2,3,4,5,6-pentafluorostyrene 
• 344-04-7 bromopentafluorobenzene 
• 653-37-2 perfluorobenzaldehyde 
• 653-30-5 (pentafluorophenyl)acetonitrile 
• 771-56-2 2,3,4,5,6-pentafluorotoluene 
• 827-15-6 1,2,3,4,5-pentafluoro-6-iodobenzene 
• 440-60-8 (2,3,4,5,6-pentafluorophenyl)methanol 
• 653-35-0 2,3,4,5,6-pentafluorobenzyl chloride 
• 1765-40-8 (bromomethyl)pentafluorobenzene 
• 75-21-8 oxirane 
• 879-06-1 pentafluorophenylmagnesium chloride 
• 879-05-0 2,3,4,5,6-pentafluorophenylmagnesium bromide 

Downstream Products

• 178685-11-5 1,2,3,4,5-Pentafluoro-6-(2-iodo-ethyl)-benzene 
• 1350703-24-0 2-pentafluorophenylethyl β-D-glucopyranoside 
• 653-34-9 2,3,4,5,6-pentafluorostyrene 
• 201156-98-1 2-Methoxy-5,5-dimethyl-2-(2-pentafluorophenyl-ethoxy)-2,5-dihydro-[1,3,4]oxadiazole 
• 2412-72-8 2-Pentafluorophenylethyl bromide 

Relevant articles and documents

Direct Ruthenium-Catalyzed Hydrogenation of Carboxylic Acids to Alcohols

The "green" reduction of carboxylic acids to alcohols is a challenging task in organic chemistry. Herein, we describe a general protocol for generation of alcohols by catalytic hydrogenation of carboxylic acids. Key to success is the use of a combination of Ru(acac)3, triphos and Lewis acids. The novel method showed broad substrate tolerance and a variety of aliphatic carboxylic acids including biomass-derived compounds can be smoothly reduced.

Regioselective hydroboration-oxidation and -amination of fluoro-substituted styrenes

Hydroboration of fluorinated styrenes with common hydroborating agents results in polymerization. However, regioselective hydroboration has been achieved by utilizing iodoborane-dimethyl sulfide. A series of fluorinated β-phenethyl alcohols and amines were synthesized via this methodology.

Markovnikov hydroboration of perfluoroalkylethylenes

A Markovnikov regioselectivity of 92% or higher is achieved in the hydroboration of a series of perfluoroalkylethylenes and 2',3',4',5',6'- pentafluorostyrene with dichloro- and dibromoborane to provide the corresponding (fluoroalkyl)dihaloboranes (see reaction).