65325-68-0

Basic information

• Product Name: [(fluoromethyl)sulfinyl]benzene
• CAS NO: 65325-68-0
• Molecular Formula: C₇H₇FOS
• Molecular Weight: 158.1933
• Mol File: 65325-68-0.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 283.1°C at 760 mmHg
• Flash Point: 125°C
• Density: 1.29g/cm³
• Vapor Pressure: 0.00551mmHg at 25°C
• Refractive Index: 1.574
• CAS DataBase Reference: [(fluoromethyl)sulfinyl]benzene(CAS DataBase Reference)
• NIST Chemistry Reference: [(fluoromethyl)sulfinyl]benzene(65325-68-0)
• EPA Substance Registry System: [(fluoromethyl)sulfinyl]benzene(65325-68-0)

Safety Data

• Hazardous Substances Data: 65325-68-0(Hazardous Substances Data)

Usage

General Description

[(Fluoromethyl)sulfinyl]benzene is a chemical compound with the molecular formula C7H7FSO. It is a member of the sulfoxide family and is characterized by its benzene ring structure with a sulfinyl group and a fluoromethyl substituent. [(fluoromethyl)sulfinyl]benzene is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also utilized as a precursor for the preparation of sulfoxide derivatives, which have various industrial applications. Additionally, [(fluoromethyl)sulfinyl]benzene has been studied for its potential use as a reagent in organic chemistry, particularly in the formation of carbon-carbon and carbon-heteroatom bonds. However, as a fluorinated compound, it is important to handle [(fluoromethyl)sulfinyl]benzene with caution due to its potential toxicity and environmental impact.

Upstream product

• 60839-94-3 2-fluoro-methylthiobenzene 
• 100-68-5 methyl-phenyl-thioether 
• 593-70-4 R₃₂ 
• 930-69-8 sodium thiophenolate 
• 108-98-5 thiophenol 
• 1193-82-4 racemic methyl phenyl sulfoxide 
• 7205-91-6 phenylthiomethyl chloride 

Downstream Products

• 92540-81-3 2-Benzenesulfinyl-3-phenyl-1-p-tolyl-aziridine 
• 85970-51-0 (1-Fluoro-tridecane-1-sulfinyl)-benzene 
• 60839-94-3 2-fluoro-methylthiobenzene 
• 1535-67-7 difluoromethyl phenyl sulfide 
• 81931-98-8 1-<(Difluoromethyl)thio>-4-methoxybenzene 
• 1193-82-4 racemic methyl phenyl sulfoxide 
• 337-72-4 2-fluoro-1,1-diphenylethan-1-ol 
• 23975-23-7 2-benzenesulfinyl-1,1-diphenylethanol 
• 945-51-7 1,1'-sulfinylbisbenzene 
• 117939-92-1 n-hexyl phenyl sulfoxide 
• 450-94-2 2-fluoro-1-phenylethanol 
• 4170-69-8 isopropyl phenyl sulfoxide 
• 1674-30-2 1-phenyl-2-chloroethanol 

Relevant articles and documents

Novel process for synthesizing 2 -fluorocyclopropylamine with high selectivity and asymmetric synthesis

A novel highly selective asymmetric synthesis process of 2 -fluorocyclopropylamine (Structural I). The method provided by the invention uses 1 - fluorine -1 - benzene (propylene) sulfonyl methane and chiral epichlorohydrin to construct chiral cyclopropane under basic conditions, and a new synthetic route not only achieves a special cis-trans selectivity, but also has a highly specific stereoselectivity. The synthesis route is efficient, the reaction condition is mild, the method is suitable for large industrial production in a green environment, 2 -fluorocyclopropylamine production cost is greatly reduced.

Diastereoselective Monofluorocyclopropanation Using Fluoromethylsulfonium Salts

Diarylfluoromethylsulfonium salts, alternatives to freons or advanced fluorinated building blocks, are bench stable and easy-to-use sources of direct fluoromethylene (:CHF) transfer to alkenes. These salts enabled development of a trans-selective monofluorinated Johnson-Corey-Chaykovsky reaction with vinyl sulfones or vinyl sulfonamides to access synthetically challenging monofluorocyclopropane scaffolds. The described method offers rapid access to monofluorinated cyclopropane building blocks with further functionalization opportunities to deliver more complex synthetic targets diastereoselectively.

Fluorinated trimethyllysine as a 19F NMR probe for trimethyllysine hydroxylase catalysis

Trimethyllysine hydroxylase (TMLH) catalyses C-3 hydroxylation of Nε-trimethyllysine in the first step of carnitine biosynthesis in humans. Studies on TMLH have been hampered by the lack of established chemical methods. We report that an N