65610-64-2

Basic information

• Product Name: 1H-Indole-1-carboxylic acid, 3-methyl-
• CAS NO: 65610-64-2
• Molecular Formula: C10H9NO2
• Molecular Weight: 175.187
• Mol File: 65610-64-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1H-Indole-1-carboxylic acid, 3-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-1-carboxylic acid, 3-methyl-(65610-64-2)
• EPA Substance Registry System: 1H-Indole-1-carboxylic acid, 3-methyl-(65610-64-2)

Safety Data

• Hazardous Substances Data: 65610-64-2(Hazardous Substances Data)

Upstream product

• 83-34-1 3-Methylindole 
• 124-38-9 carbon dioxide 

Downstream Products

• 800369-69-1 diphenyl-2-(3-methylindolyl)phosphine 
• 1264291-73-7 N-(2-(2,2-dibromovinyl)phenyl)-3-methyl-1H-indole-1-carboxamide 
• 83-34-1 3-Methylindole 
• 1616116-01-8 N-methoxy-3-methyl-2-phenyl-1H-indole-1-carboxamide 

Relevant articles and documents

Ruthenium(II)-Catalyzed Regio- and Stereoselective C-H Allylation of Indoles with Allyl Alcohols

A ruthenium-catalyzed C-H allylation of indoles with allyl alcohols via β-hydroxide elimination is reported. Without external oxidants and expensive additives, this reaction features mild reaction conditions, compatibility with various functional groups, and good to excellent regioselectivity and stereoselectivity.

Ruthenium(II)-Catalyzed Redox-Neutral [3+2] Annulation of Indoles with Internal Alkynes via C-H Bond Activation: Accessing a Pyrroloindolone Scaffold

Ru(II)-catalyzed redox-neutral [3+2] annulation reactions of N-ethoxycarbamoyl indoles and internal alkynes via C-H bond activation are reported. This method features a broad internal alkyne scope, including various aryl/alkyl-, alkyl/alkyl-, and diaryl-substituted alkynes, good to excellent regioselectivity, diverse functional group tolerance, and mild reaction conditions. The N-ethoxycarbamoyl directing group, temperature, CsOAc, and ruthenium catalyst proved to be crucial for conversion and high regioselectivity. Additionally, preliminary mechanistic experiments were conducted, and a possible mechanism was proposed.

Rh(III)-catalyzed selective coupling of N-methoxy-1H-indole-1-carboxamides and aryl boronic acids

A Rh(III)-catalyzed selective coupling of N-methoxy-1H-indole-1-carboxamide and aryl boronic acids is reported. The coupling is mild and efficient toward diverse product formation, with selective C-C and C-C/C-N bond formation. Kinetic isotope effects studies were conducted to reveal a mechanism of C-H activation and electrophilic addition.