657398-80-6

Basic information

• Product Name: 4-{4-[3-(6-methylpyridin-2-yl)-1-trityl-1h-pyrazol-4-yl]pyridin-2-yl-}phenol
• Synonyms: 4-{4-[3-(6-methylpyridin-2-yl)-1-trityl-1h-pyrazol-4-yl]pyridin-2-yl-}phenol
• CAS NO: 657398-80-6
• Molecular Weight: 570.693
• Mol File: 657398-80-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-{4-[3-(6-methylpyridin-2-yl)-1-trityl-1h-pyrazol-4-yl]pyridin-2-yl-}phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-{4-[3-(6-methylpyridin-2-yl)-1-trityl-1h-pyrazol-4-yl]pyridin-2-yl-}phenol(657398-80-6)
• EPA Substance Registry System: 4-{4-[3-(6-methylpyridin-2-yl)-1-trityl-1h-pyrazol-4-yl]pyridin-2-yl-}phenol(657398-80-6)

Safety Data

• Hazardous Substances Data: 657398-80-6(Hazardous Substances Data)

Upstream product

• 446880-84-8 2-bromo-4-(3-(6-methylpyridin-2-yl)-1-trityl-1H-pyrazol-4-yl)pyridine 
• 1106870-09-0 4-hydroxyphenyl boronic acid pinacol ester 
• 269409-70-3 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol 

Downstream Products

• 657398-99-7 C₄₄H₃₆N₆O 

Relevant articles and documents

PYRAZOLE INHIBITORS OF THE TRANSFORMING GROWTH FACTOR

The invention relates to novel pyrazole derivatives of formula (I), which are inhibitors of the transforming growth factor, ("TGF")-? signalling pathway, in particular, the phosphorylation of smad2 or smad3 by the TGF-β type I or activin-like kinase ("ALK")-5 receptor, methods for their preparation and their use in medicine, specifically in the treatment and prevention of a disease state mediated by this pathway.