659-77-8

Basic information

• Product Name: 11-hydroxybimol.cyclic ester ;;
• CAS NO: 659-77-8
• Molecular Weight: 368.557
• Mol File: 659-77-8.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: 11-hydroxybimol.cyclic ester ;;(CAS DataBase Reference)
• NIST Chemistry Reference: 11-hydroxybimol.cyclic ester ;;(659-77-8)
• EPA Substance Registry System: 11-hydroxybimol.cyclic ester ;;(659-77-8)

Safety Data

• Hazardous Substances Data: 659-77-8(Hazardous Substances Data)

Upstream product

• 24724-07-0 methyl 11-hydroxyundecanoate 
• 3669-80-5 11-hydroxyundecanoic acid 
• 109182-97-0 Acrylic acid 8-iodo-octyl ester 
• 63632-65-5 11-iodo-undecanoic acid 
• 2834-05-1 11-bromoundecanoic acid 

Relevant articles and documents

An improved and novel approach to macrolactonisation using di-tert-butyl dicarbonate

A new, facile, mild and simple method for the synthesis of macrolides was achieved from ω- hydroxy acids using di-tertbutyl dicarbonate (Boc2O), a cheap and commercially available reagent. A wide range of substrates were tested and give good yield of lactones. The effect of various simple bases on the yield of the macrolactonisation reaction was also studied.

A new method for the lactonization of ω-hydroxy carboxylic acids with Di-2-thienyl carbonate by the promotion of DMAP and iodine

Successive reactions of ω-hydroxycarboxylic acids with an equimolar amount of di-2-thienyl carbonate (2-DTC) in the presence of a catalytic amount of 4-(dimethylamino)pyridine (DMAP) followed by an addition of 2-4 equimolar amounts of iodine afforded the corresponding lactones in good to high yields. Copyright

A new method for the synthesis of carboxylic esters and lactones with di-2-thienyl carbonate (2-DTC) by the promotion of DMAP and iodine

The esterification of carboxylic acids with alcohols by using di-2-thienyl carbonate (2-DTC) in the presence of a catalytic amount of 4-(dimethylamino) pyridine (DMAP) proceeded smoothly to afford the corresponding esters in good-to-high yields along with 2(5H)-thiophenone. This esterification was accelerated by the addition of an equimolar amount of iodine to afford the esters in higher yields within a shorter reaction time. Further, cyclization of ω-hydroxycarboxylic acids with an equimolar amount of 2-DTC in the presence of a catalytic amount of DMAP, followed by the addition of 1-4 equimolar amounts of iodine, afforded the corresponding lactones in good-to-high yields under mild conditions. This method was successfully employed in the synthesis of erythro-aleuritic acid lactone.