6602-64-8

Basic information

• Product Name: CYCLOHEXYL 2-PYRIDYL KETONE
• Synonyms: CYCLOHEXYL-PYRIDIN-2-YL-METHANONE;CYCLOHEXYL 2-PYRIDYL KETONE
• CAS NO: 6602-64-8
• Molecular Formula: C₁₂H₁₅NO
• Molecular Weight: 189.25
• Mol File: 6602-64-8.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 301.3°C at 760 mmHg
• Flash Point: 143.9°C
• Appearance: /
• Density: 1.071g/cm³
• Vapor Pressure: 0.00106mmHg at 25°C
• Refractive Index: 1.539
• CAS DataBase Reference: CYCLOHEXYL 2-PYRIDYL KETONE(CAS DataBase Reference)
• NIST Chemistry Reference: CYCLOHEXYL 2-PYRIDYL KETONE(6602-64-8)
• EPA Substance Registry System: CYCLOHEXYL 2-PYRIDYL KETONE(6602-64-8)

Safety Data

• Hazardous Substances Data: 6602-64-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H15NO/c14-12(10-6-2-1-3-7-10)11-8-4-5-9-13-11/h4-5,8-10H,1-3,6-7H2

Upstream product

• 13737-05-8 2-trimethylstannylpyridine 
• 2719-27-9 cyclohexanylcarbonyl chloride 
• 98-89-5 Cyclohexanecarboxylic acid 
• 1121-60-4 pyridine-2-carbaldehyde 
• 126812-30-4 1,3-dioxoisoindolin-2-yl cyclohexanecarboxylate 
• 109-04-6 2-bromo-pyridine 
• 100-70-9 2-Cyanopyridine 
• 931-50-0 cyclohexylmagnesium bromide 
• 98-98-6 2-Picolinic acid 
• 2043-61-0 cyclohexanecarbaldehyde 
• 931-51-1 cyclohexylmagnesiumchloride 
• 70423-45-9 2-((cyclohexyl)hydroxymethyl)pyridine 

Downstream Products

• 379226-45-6 Cyclohexyl-(2-pyridyl)-methanone-(1,3-benzothiazol-2-yl)-hydrazone 

Relevant articles and documents

Visible Light-Driven Decarboxylative Alkylation of Aldehydes via Electron Donor–Acceptor Complexes of Active Esters

There are some synthesis methods from widely available aldehydes to the corresponding ketones, however, they involved in multistep reactions with Grignard’s reagents or transition metal catalysts. In this paper, we have developed photocatalyst-free and visible light-driven decarboxylative alkylation of pyridinaldehydes. The photochemical reactions are initiated via photoinduced single electron transfer from triethylamine to N-hydroxyphthalimide esters in electron donor–acceptor complexes. This photochemical method can achieve to translate 15 pyridinaldehydes and 11 2-quinolinaldehydes to the corresponding ketones. Furthermore, this strategy can also achieve two other transformations, disulfanes to aryl sulfides and a styrene sulfone to the alkyl-substituted alkene.

Pd-Catalyzed Alkylation of (Iso)quinolines and Arenes: 2-Acylpyridine Compounds as Alkylation Reagents

The first Pd-catalyzed alkylation of (iso)quinolines and arenes is reported. The readily available and bench-stable 2-acylpyridine compounds were used as an alkylation reagent to form the structurally versatile alkylated (iso)quinolines and arenes. The method affords a convenient pathway for the introduction of alkyl groups into organic molecules.

Facile preparation of aromatic ketones from aromatic bromides and arenes with aldehydes

Aromatic ketones were efficiently prepared in good yields by the reactions of aryl bromides with n-BuLi, followed by the reactions with aromatic aldehydes or aliphatic aldehydes and the subsequent treatment with molecular iodine and K2CO3, in a one-pot method. The same treatment of arenes, instead of aromatic bromides, also provided the corresponding aromatic ketones in good yields. Using these methods, various diaryl ketones and alkyl aryl ketones bearing electron-rich aromatics and electron-deficient aromatics could be prepared efficiently by a simple, transition-metal-free, and therefore environmentally benign experimental procedure.