66185-72-6

Basic information

• Product Name: 2H-1-Benzopyran-2-one, 7-(benzoyloxy)-4-methyl-
• CAS NO: 66185-72-6
• Molecular Formula: C17H12O4
• Molecular Weight: 280.28
• Mol File: 66185-72-6.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 2H-1-Benzopyran-2-one, 7-(benzoyloxy)-4-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-1-Benzopyran-2-one, 7-(benzoyloxy)-4-methyl-(66185-72-6)
• EPA Substance Registry System: 2H-1-Benzopyran-2-one, 7-(benzoyloxy)-4-methyl-(66185-72-6)

Safety Data

• Hazardous Substances Data: 66185-72-6(Hazardous Substances Data)

Upstream product

• 90-33-5 7-hydroxy-4-methyl-chromen-2-one 
• 108-46-3 recorcinol 
• 93-97-0 benzoic acid anhydride 
• 65-85-0 benzoic acid 
• 98-88-4 benzoyl chloride 

Downstream Products

• 20312-83-8 8-Benzoyl-7-hydroxy-4-methylcoumarin 
• 6748-68-1 8-acetyl-7-hydroxycoumarin 
• 2555-29-5 8-acetyl-7-hydroxy-4-methyl-2H-chromen-2-one 
• 90104-85-1 8-Benzoyl-7-hydroxycoumarin 
• 68454-14-8 8-benzoyloxy-7-hydroxy-4-methylcoumarin 
• 67839-94-5 4-methyl-7-hydroxy-6-benzoylchromen-2-one 
• 86882-62-4 8-benzoyl-4-methyl-9-phenyl-2H-furo[2,3-h]chropmen-2-one 
• 424807-26-1 (8-benzoyl-4-methyl-2-oxo-2H-chromen-7-yloxy)-acetic acid ethyl ester 
• 113765-91-6 (8-benzoyl-4-methyl-2-oxo-2H-chromen-7-yloxy)-acetic acid 
• 113765-92-7 4-methyl-9-phenylfuro[2,3-h]chromen-2-one 
• 25855-75-8 (2,6-dimethoxyphenyl)(phenyl)methanone 
• 63411-81-4 benzoyl-resorcinol 
• 245728-25-0 8-Benzoyl-7-hydroxy-4-methylcoumarin oxime 
• 90-33-5 7-hydroxy-4-methyl-chromen-2-one 

Relevant articles and documents

Tris(pentafluorophenyl)borane catalyzed acylation of alcohols, phenols, amines, and thiophenols under solvent-free condition

The acylation of alcohols, phenols, amines, and thiophenols was accomplished with 0.5 mol % of tris(pentafluorophenyl)borane [B(C 6F5)3] at ambient temperature under solvent-free condition. Major advantages of this method include high yield, short reaction time, simple procedure, compatibility with sensitive protecting groups as well as other functional groups, absence of racemization of optical active compounds, and epimerization of sugars.

Synthesis, spectral characterization and α-chymotrypsin activity of 7-O-substituted derivatives of 7-hydroxy-4-methyl-1-benzopyran-2-one

In this work, a series of O-alkyl/arenyl/acyl substituted derivatives of 7-hydorxy-4-methyl-1-benzenpyran-2-one (3a-l) was synthesized. The parent compound 7-hydroxy-4-methyl-1-benzenpyran-2-one (1) was geared up by the coupling of resorcinol (a) with ethylacetoacetate (b) in the presence of conc. sulphuric acid. Further, O-substituted derivatives of parent compound were prepared by treating with different electrophiles (2a-l) using sodium hydride as base and DMF as a solvent. The structure of these synthesized compounds were characterized by IR, EI-MS and 1H NMR. These derivatives were also screened against α-chymotrypsin enzyme to check their enzyme inhibition activity. All the compounds displayed a-chymotrypsin activity to varying degree.

An efficient, mild and scalable synthesis of bioactive compounds containing the angelicin scaffold

An efficient, mild and scalable synthesis of angelicin scaffold based compounds was developed. Particularly, the new synthetic route described here circumvents the need for the previously reported key Fries rearrangement step, which uses impractically har