68454-14-8

Basic information

• Product Name: 8-benzoyloxy-7-hydroxy-4-methylcoumarin
• Synonyms: 8-benzoyloxy-7-hydroxy-4-methylcoumarin
• CAS NO: 68454-14-8
• Molecular Weight: 296.279
• Mol File: 68454-14-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 8-benzoyloxy-7-hydroxy-4-methylcoumarin(CAS DataBase Reference)
• NIST Chemistry Reference: 8-benzoyloxy-7-hydroxy-4-methylcoumarin(68454-14-8)
• EPA Substance Registry System: 8-benzoyloxy-7-hydroxy-4-methylcoumarin(68454-14-8)

Safety Data

• Hazardous Substances Data: 68454-14-8(Hazardous Substances Data)

Upstream product

• 2107-77-9 4-methyldaphnetin 
• 93-97-0 benzoic acid anhydride 
• 66185-72-6 7-(phenylcarbonyl)oxy-4-methyl-2H-1-benzopyran-2-one 

Downstream Products

• 86882-62-4 8-benzoyl-4-methyl-9-phenyl-2H-furo[2,3-h]chropmen-2-one 

Relevant articles and documents

Biocatalytic synthesis of novel partial esters of a bioactive dihydroxy 4-methylcoumarin by Rhizopus oryzae lipase (ROL)

Highly regioselective acylation has been observed in 7,8-dihydroxy-4-methylcoumarin (DHMC) by the lipase from Rhizopus oryzae suspended in tetrahydrofuran (THF) at 45°C using six different acid anhydrides as acylating agents. The acylation occurred regioselectively at one of the two hydroxy groups of the coumarin moiety resulting in the formation of 8-acyloxy-7-hydroxy-4-methylcoumarins, which are important bioactive molecules for studying biotansformations in animals, and are otherwise very difficult to obtain by only chemical steps. Six monoacylated, monohydroxy 4-methylcoumarins have been biocatalytically synthesised and identified on the basis of their spectral data and X-ray crystal analysis.

COUMARIN COMPOUNDS AND THEIR USE FOR TREATING CANCER

Coumarin compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, and X are defined herein. Also disclosed is a method for treating cancer with coumarin compounds.