663-73-0

Basic information

• Product Name: 2,2,3,3-TETRAFLUOROPROPIONYL CHLORIDE
• Synonyms: 3H-TETRAFLUOROPROPIONYL CHLORIDE;2,2,3,3-TETRAFLUOROPROPIONYL CHLORIDE;DAIKIN C-5208;2,2,3,3-Tetrafluoropropionyl chloride 97%;2,2,3,3-Tetrafluoropropionylchloride97%;3H-TETRAFLUOROPROPIONYL CHLORIDE 97%;2,2,3,3-tetrafluoropropanoyl chloride;propanoyl chloride, 2,2,3,3-tetrafluoro-
• CAS NO: 663-73-0
• Molecular Formula: C₃HClF₄O
• Molecular Weight: 164.49
• EINECS: -0
• Mol File: 663-73-0.mol
• Article Data: 4

Chemical Properties

• Melting Point: 38-40 °C
• Boiling Point: 37 °C
• Flash Point: 38-40°C
• Appearance: /
• Density: 1.512
• Vapor Pressure: 328mmHg at 25°C
• Refractive Index: 1.325
• Sensitive: Moisture Sensitive
• BRN: 1766339
• CAS DataBase Reference: 2,2,3,3-TETRAFLUOROPROPIONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,3,3-TETRAFLUOROPROPIONYL CHLORIDE(663-73-0)
• EPA Substance Registry System: 2,2,3,3-TETRAFLUOROPROPIONYL CHLORIDE(663-73-0)

Safety Data

• Hazard Codes: C,T
• Statements: 34-25
• Safety Statements: 26-36/37/39-45
• RIDADR: 3265
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 663-73-0(Hazardous Substances Data)

Usage

General Description

2,2,3,3-Tetrafluoropropionyl chloride, also known as heptafluoropropionyl chloride, is a chemical compound with the formula C3ClF4O. It is a colorless liquid with a pungent odor and is highly reactive. It is primarily used in the synthesis of pharmaceuticals and agrochemicals, as well as in the production of fluorinated polymers and surfactants. Due to its high reactivity, it is handled and stored under strict safety precautions, as it can cause severe skin and eye irritation and is harmful if inhaled or ingested. Its main application is as an intermediate in the production of various chemicals and materials.

InChI:InChI=1/C3HClF4O/c4-1(9)3(7,8)2(5)6/h2H

Upstream product

• 2317-76-2 tri(2,2,3,3-tetrafluoropropyl) borate 
• 756-09-2 2,2,3,3-tetrafluoropropanoic acid 
• 98-88-4 benzoyl chloride 

Downstream Products

• 1391943-74-0 (E)-methyl 3-(2-chloro-6-fluorophenyl)-5-(1-(dimethylamino)-4,4,5,5-tetrafluoro-3-oxopent-1-en-2-yl)isoxazole-4-carboxylate 
• 717-96-4 2,2,3,3-tetrafluoro-propionic acid anilide 

Relevant articles and documents

Identification of (R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitabl

Polycomb repressive complex 2 (PRC2) has been shown to play a major role in transcriptional silencing in part by installing methylation marks on lysine 27 of histone 3. Dysregulation of PRC2 function correlates with certain malignancies and poor prognosis

EINSTUFIGE HERSTELLUNG HALOGENIERTER CARBONSAUREFLUORIDE AUS DEN FREIEN SAUREN

The reaction of per- or polyhalogenated carboxylic acids with trifluoromethyl or difluorochloromethyl substituted aromatics takes place in the presence of Lewis-acid-catalysts and forms the corresponding acid fluorides in good to very good yields.