6630-90-6

Basic information

• Product Name: diethyl 2,4-diacetyl-3-(4-methoxyphenyl)pentanedioate
• Synonyms: 2,4-Diacetyl-3-(4-methoxy-phenyl)-pentanedioic acid diethyl ester; pentanedioic acid, 2,4-diacetyl-3-(4-methoxyphenyl)-, diethyl ester
• CAS NO: 6630-90-6
• Molecular Formula: C₂₀H₂₆O₇
• Molecular Weight: 378.4162
• Mol File: 6630-90-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 498°C at 760 mmHg
• Flash Point: 215.6°C
• Density: 1.144g/cm³
• Vapor Pressure: 4.71E-10mmHg at 25°C
• Refractive Index: 1.498
• CAS DataBase Reference: diethyl 2,4-diacetyl-3-(4-methoxyphenyl)pentanedioate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl 2,4-diacetyl-3-(4-methoxyphenyl)pentanedioate(6630-90-6)
• EPA Substance Registry System: diethyl 2,4-diacetyl-3-(4-methoxyphenyl)pentanedioate(6630-90-6)

Safety Data

• Hazardous Substances Data: 6630-90-6(Hazardous Substances Data)

Upstream product

• 141-97-9 ethyl acetoacetate 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 57171-24-1 3-(4-methoxyphenyl)glutaric anhydride 
• 33868-91-6 3-(4-methoxyphenyl)glutaric acid 
• 57100-28-4 trans-sphagnum acid 
• 106833-44-7 (E)-3-(4-methoxyphenyl)pent-2-enedioic acid 
• 80370-87-2 (5-methoxy-2,3-dihydro-1H-inden-1-yl)acetic acid 

Relevant articles and documents

Synthesis and biological evaluation of pentanedioic acid derivatives as farnesyltransferase inhibitors

Structure-based virtual screening of a commercial library identified pentanedioic acid derivatives (6 and 13b) as a kind of novel scaffold farnesyltransferase inhibitors (FTIs). Chemical modifications of the lead compounds, biological assays and analysis of the structure-activity relationships (SAR) were conducted to discover more potent FTIs. Some of them displayed excellent inhibition against FTase, and among them, the most active compound 13n with an IC50 value of 0.0029 μM and SAR analysis might be helpful to the discovery of more potent FTIs. This journal is

Syntheses of bryophyte constituents. 8. Sphagnum acid and its degradation products

For Sphagnum acid (1) and its enzymatic degradation product 5-hydroxy-4-(4-hydroxyphenyl)-5H-furan-2-on (2) efficient syntheses on preparative scale were developed. For the (4-hydroxyphenyl)butenolide 2 some characteristic chemical transformations are observed in acidic and basic medium. Johann Ambrosius Barth 1996.