6633-46-1 Usage
Description
3-Hydroxyfluoren-9-one, also known as 3-Hydroxy-9H-fluoren-9-one, is a metabolite derived from polycyclic aromatic hydrocarbons (PAH). It is a compound with a unique chemical structure that has attracted attention for its potential applications in various fields.
Uses
Used in Environmental Monitoring:
3-Hydroxyfluoren-9-one is used as a biomarker for monitoring human exposure to PAHs. The presence and levels of this metabolite in biological samples can indicate the extent of exposure to PAHs, which are known to have adverse health effects.
Used in Toxicology Research:
In the field of toxicology, 3-hydroxyfluoren-9-one serves as a valuable tool for studying the toxic effects of PAHs on human health. By analyzing the levels of this metabolite, researchers can gain insights into the mechanisms of PAH-induced toxicity and develop strategies for prevention and treatment.
Used in Analytical Chemistry:
3-Hydroxyfluoren-9-one can be employed as a reference compound in the development and validation of analytical methods for the detection and quantification of PAHs in environmental and biological samples. Its unique chemical properties make it a suitable candidate for improving the accuracy and reliability of such methods.
Used in Pharmaceutical Research:
Due to its structural similarities with PAHs, 3-hydroxyfluoren-9-one may also have potential applications in the development of new drugs targeting PAH-related diseases or conditions. Researchers can use this compound as a starting point for designing novel therapeutic agents with improved safety and efficacy profiles.
Check Digit Verification of cas no
The CAS Registry Mumber 6633-46-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,6,3 and 3 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 6633-46:
(6*6)+(5*6)+(4*3)+(3*3)+(2*4)+(1*6)=101
101 % 10 = 1
So 6633-46-1 is a valid CAS Registry Number.
InChI:InChI=1/C13H8O2/c14-8-5-6-11-12(7-8)9-3-1-2-4-10(9)13(11)15/h1-7,14H
6633-46-1Relevant articles and documents
Palladium catalyzed domino C-H activation strategy: An access to 9- fluorenones
Patel, Anuj,Shaikh, Mahommedumar,Chikhalia, Kishor
supporting information, p. 236 - 245 (2018/12/11)
Palladium catalyzed domino C-H functionalization reaction of arylaldehyde with dihaloarene has been developed to access 9-flourenone molecules. Bidentate ligand assisted strategy, single step reaction, high yield and excellent functional group tolerance make this method concise and effective for the synthesis of 9-flourenone. In addition, proposed method has been successfully employed to synthesise Tilorone in gram scale.
Synthesis of fluorenone derivatives through Pd-catalyzed dehydrogenative cyclization
Li, Hu,Zhu, Ru-Yi,Shi, Wen-Juan,He, Ke-Han,Shi, Zhang-Jie
supporting information, p. 4850 - 4853,4 (2012/12/12)
Palladium-catalyzed dual C-H functionalization of benzophenones to form fluorenones by oxidative dehydrogenative cyclization is reported. This method provides a concise and effective route toward the synthesis of fluorenone derivatives, which shows outstanding functional group compatibility.
