66353-38-6Relevant articles and documents
Substituted (2-Phenoxyphenyl)acetic Acids with Antiinflammatory Activity. 1
Atkinson, David C.,Godfrey, Keith E.,Meek, Bernard,Saville, John F.,Stillings, Michael R.
, p. 1353 - 1360 (2007/10/02)
The synthesis and antiinflammatory activity of a series of substituted (2-phenoxyphenyl)acetic acids are described.Initial screening in the adjuvant arthritis test showed that halogen substitution in the phenoxy ring enhanced activity considerably.Ulcerogenic potential, as measured by the minimum ulcerogenic dose (MUD), was low in almost all the acids tested. acetic acid possessed the most favorable combination of potency with low toxicity, including ulcerogenicity, and this compound is now in therapeutic use.
Benz-acylbenzimidazole-2-carboxylic acid derivatives
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, (2008/06/13)
New heterocyclylcarboxylic acid derivatives which are acylated in the nucleus, especially benz-acyl-benzimidazole-2-carboxylic acid derivatives of the formula STR1 in which R is a free, esterified or amidated carboxyl group or a free, etherified or esterified hydroxymethyl group, R1 is an aliphatic, cycloaliphatic, aromatic, araliphatic, heterocyclic or heterocyclic-aliphatic radical, R2 is hydrogen or an aliphatic radical and Ph is a 1,2-phenylene group containing the radical R1 --C(=O)--, with the proviso that R1 contains at least 2 carbon atoms if Ph is otherwise unsubstituted, R2 is ethyl and R is acetoxymethyl, and salts of such compounds having salt-forming properties, are useful as anti-allergic agents.