66439-03-0

Basic information

• Product Name: diethyl 1-benzyl-2,6-dimethyl-4-phenyl-1,4-dihydro-3,5-pyridinedicarboxylate
• Synonyms: diethyl 1-benzyl-2,6-dimethyl-4-phenyl-1,4-dihydro-3,5-pyridinedicarboxylate
• CAS NO: 66439-03-0
• Molecular Formula: C₂₆H₂₉NO₄
• Molecular Weight: 419.51276
• Mol File: 66439-03-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: diethyl 1-benzyl-2,6-dimethyl-4-phenyl-1,4-dihydro-3,5-pyridinedicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl 1-benzyl-2,6-dimethyl-4-phenyl-1,4-dihydro-3,5-pyridinedicarboxylate(66439-03-0)
• EPA Substance Registry System: diethyl 1-benzyl-2,6-dimethyl-4-phenyl-1,4-dihydro-3,5-pyridinedicarboxylate(66439-03-0)

Safety Data

• Hazardous Substances Data: 66439-03-0(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 141-97-9 ethyl acetoacetate 
• 100-46-9 benzylamine 
• 1165-06-6 Diethyl 2,6-dimethyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate 
• 100-39-0 benzyl bromide 
• 100-44-7 benzyl chloride 
• 21759-74-0 ethyl (Z)-3-(benzylamino)-2-butenoate 
• 127896-76-8 N-(1-chlorobenzyl)pyridinium chloride 
• 3287-99-8 benzylamine hydrochloride 

Relevant articles and documents

Research on heterocyclic compounds. XLIII. Synthetic studies on 1,4-dihydropyridine derivatives

In order to obtain N-benzyl-3,5-dicarbethoxy-2,6-dimethyl-4-phenyl-1,4-dihydropyridine 1 as a lead compound of pharmacological interest, the classical Hantzsch synthetic method and the modified Collie procedure were used. However, only a very low yield of

1-ARYL- AND 1-BENZYL-3,5-DIETHOXYCARBONYL-1,4-DIHYDROPYRIDINES

The possibility has been studied of using anilines in the Hantzsch synthesis.It has been shown that, with the exception of those containing strong electron-accepting substituents, they take part in this reaction with the formation of 1-aryl-1,4-dihydropyridines.The reaction largely depends on the nature of the substituents in the aniline and in the benzaldehyde and is promoted by electron-accepting substituents in the aldehyde and electron-donating substituents in the amine.The mechanism of the reaction is discussed.A number of 1-benzyl-1,4-dihydroxypyridines have been synthesized.The UV, IR, and PMR spectra and the electro-oxidation of the compounds obtained have been studied.