6645-69-8

Basic information

• Product Name: (4-NITRO-PYRAZOL-1-YL)-ACETIC ACID
• Synonyms: TIMTEC-BB SBB000166;ART-CHEM-BB B000219;CHEMBRDG-BB 5913009;(4-NITRO-PYRAZOL-1-YL)-ACETIC ACID;(4-NITRO-1H-PYRAZOL-1-YL)ACETIC ACID;AKOS B000219;AKOS PAO-0916;2-(4-NITRO-1H-PYRAZOL-1-YL)ACETIC ACID
• CAS NO: 6645-69-8
• Molecular Formula: C₅H₅N₃O₄
• Molecular Weight: 171.11
• Mol File: 6645-69-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 416.4°C at 760 mmHg
• Flash Point: 205.6°C
• Appearance: /
• Density: 1.71g/cm³
• Vapor Pressure: 1.11E-07mmHg at 25°C
• Refractive Index: 1.671
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (4-NITRO-PYRAZOL-1-YL)-ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (4-NITRO-PYRAZOL-1-YL)-ACETIC ACID(6645-69-8)
• EPA Substance Registry System: (4-NITRO-PYRAZOL-1-YL)-ACETIC ACID(6645-69-8)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 6645-69-8(Hazardous Substances Data)

Usage

Description

(4-NITRO-PYRAZOL-1-YL)-ACETIC ACID is an organic compound with the molecular structure featuring a nitro group attached to a pyrazole ring, which is further connected to an acetic acid group. (4-NITRO-PYRAZOL-1-YL)-ACETIC ACID is known for its potential applications in the pharmaceutical and medical fields due to its unique chemical properties and reactivity.

Uses

Used in Pharmaceutical Industry:
(4-NITRO-PYRAZOL-1-YL)-ACETIC ACID is used as a key intermediate in the synthesis of various pharmaceutical compounds, particularly those with potential therapeutic applications. Its unique structure allows for the development of new drugs with specific targeting and activity profiles.
Used in Ophthalmology Research:
(4-NITRO-PYRAZOL-1-YL)-ACETIC ACID is used as a research compound for studying the effects of C-nitropyrazoles and C-nitroazoles on ocular blood flow and retinal function recovery after ischemic insult. This application is crucial in understanding the potential therapeutic benefits of these compounds in treating eye-related conditions and disorders.

InChI:InChI=1/C5H5N3O4/c9-5(10)3-7-2-4(1-6-7)8(11)12/h1-2H,3H2,(H,9,10)

Upstream product

• 2075-46-9 4-nitro-1H-pyrazole 
• 79-08-3 bromoacetic acid 
• 10199-61-8 pyrazol-1-yl acetic acid ethyl ester 
• 39753-81-6 ethyl 2-(4-nitro-1H-pyrazol-1-yl)acetate 

Downstream Products

• 786681-72-9 N-(2,3-difluorophenyl)-2-(4-nitro-1H-pyrazol-1-yl)acetamide 
• 914490-01-0 2-(4-nitro-pyrazol-1-yl)-N-phenyl-acetamide 
• 914490-03-2 2-(4-amino-pyrazol-1-yl)-N-phenyl-acetamide 
• 786681-61-6 N-(3-fluorophenyl)-2-(4-nitro-1H-pyrazol-1-yl)acetamide 
• 786681-68-3 2-(4-amino-1H-pyrazol-1-yl)-N-(2,3-difluorophenyl)acetamide 

Relevant articles and documents

HETEROCYCLYL PYRIMIDINE ANALOGUES AS TYK2 INHIBITORS

The present invention relates to compounds of formula (I), wherein R, R1, X1 to X5 have the meaning as cited in the description and the claims. Said compounds are useful as TYK2 inhibitors for the treatment or prophylaxis

A METHOD FOR THE PREPARATION OF N-HETERYLPYRAZOLES FROM 4-NITROPYRAZOLE

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