914490-03-2

Basic information

• Product Name: 2-(4-amino-pyrazol-1-yl)-N-phenyl-acetamide
• Synonyms: 2-(4-amino-pyrazol-1-yl)-N-phenyl-acetamide
• CAS NO: 914490-03-2
• Molecular Weight: 216.242
• Mol File: 914490-03-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(4-amino-pyrazol-1-yl)-N-phenyl-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-amino-pyrazol-1-yl)-N-phenyl-acetamide(914490-03-2)
• EPA Substance Registry System: 2-(4-amino-pyrazol-1-yl)-N-phenyl-acetamide(914490-03-2)

Safety Data

• Hazardous Substances Data: 914490-03-2(Hazardous Substances Data)

Usage

Chemical Class

Pyrazole derivatives

Usage

Building block in the synthesis of pharmaceuticals and agrochemicals

Biological Activities

+ Antiviral
+ Bactericidal
+ Anti-inflammatory

Potential Medical Applications

+ Treatment of tuberculosis
+ Treatment of other infectious diseases

Materials Science Applications

+ Development of novel polymers
+ Development of nanomaterials

Upstream product

• 6645-69-8 2-(4-nitro-1H-pyrazol-1-yl)acetic acid 
• 62-53-3 aniline 
• 10199-61-8 pyrazol-1-yl acetic acid ethyl ester 
• 914490-01-0 2-(4-nitro-pyrazol-1-yl)-N-phenyl-acetamide 

Relevant articles and documents

QUINOLINE AND QUINOXALINE DERIVATIVES AS INHIBITORS OF KINASE ENZYMATIC ACTIVITY

Compounds of formula (IA) or (IB), are inhibitors of aurora kinase activity: Formula (IA), (IB) wherein -L1Y1-[CH2]z- is a linker radical wherein Y1, L1 and z are as defined in the claims; R6 is C1-C4alkoxy, hydrogen or halo; W represents a bond, -CH2-, -O-, -S-, -S(=O)2-, or -NR5- where R5 is hydrogen or C1-C4 alkyl; Q is =N-, =CH- or =C(X1)- wherein X1 is cyano, cyclopropyl or halo; linker radicals L2 are as defined in the claims; R is a radical of formula (X) or (Y): wherein R1 is a carboxylic acid group (-COOH), or an ester group which is hydrolysable by one or more intracellular carboxylesterase enzymes to a carboxylic acid group; R4 is hydrogen; or optionally substituted C1-C6 alkyl, C3-C7 cycloalkyl, aryl, aryl(C1-C6 alkyl)-, heteroaryl, heteroaryl(C1-C6 alkyl)-, -(C=O)R3, -(C=O)OR3, or -(C=O)NR3 wherein R3 is hydrogen or optionally substituted (C1-C6)alkyl, C3-C7 cycloalkyl, aryl, aryl(C1-C6 alkyl)-, heteroaryl, or heteroaryl(C1-C6 alkyl)-; R41 is hydrogen or optionally substituted C1-C6 alkyl; and D is a monocyclic heterocyclic ring of 5 or 6 ring atoms.