664981-88-8

Basic information

• Product Name: Benzenesulfonamide, N-[2-[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-propynyl]phenyl]-4-methyl -
• CAS NO: 664981-88-8
• Molecular Formula: C22H29NO3SSi
• Molecular Weight: 415.629
• Mol File: 664981-88-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzenesulfonamide, N-[2-[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-propynyl]phenyl]-4-methyl -(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonamide, N-[2-[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-propynyl]phenyl]-4-methyl -(664981-88-8)
• EPA Substance Registry System: Benzenesulfonamide, N-[2-[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-propynyl]phenyl]-4-methyl -(664981-88-8)

Safety Data

• Hazardous Substances Data: 664981-88-8(Hazardous Substances Data)

Upstream product

• 665033-45-4 2-(3-tert-butyldimethylsilyloxy-1-propynyl)-nitrobenzene 
• 609-73-4 o-nitroiodobenzene 
• 80151-24-2 3-(2-nitro-phenyl)-prop-2-yn-1-ol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 577-19-5 2-nitrophenyl bromide 
• 76782-82-6 tert-Butyldimethyl(prop-2-ynyloxy)silane 

Downstream Products

• 665033-49-8 N-[2-(3-hydroxy-prop-1-ynyl)-phenyl]-4-methyl-benzenesulfonamide 

Relevant articles and documents

Rhodium(III)-Catalyzed Cascade Cyclization/Electrophilic Amidation for the Synthesis of 3-Amidoindoles and 3-Amidofurans

A rhodium(III)-catalyzed cascade cyclization/electrophilic amidation using N-pivaloyloxylamides as the electrophilic nitrogen source has been developed. This protocol provides an efficient route for the synthesis of 3-amidoindoles and 3-amidofurans under mild conditions with good functional group tolerance. The synthetic utility of this reaction has been demonstrated through the derivatization of the 3-amidoindoles to several heterocycle-fused indoles.

A simple, two-step synthesis of 3-iodoindoles

2-Halo-anilines, protected as the corresponding sulfonamides or carbamates, can be converted very efficiently into 3-iodoindoles by sequential Sonogashira coupling with a 1-alkyne and 5-endo-dig iodocyclisation. Azaindoles can also be obtained using this methodology.