66521-59-3Relevant articles and documents
Further studies on the application of vinylogous amides and β-halovinylaldehydes to the regiospecific synthesis of unsymmetrical, polyfunctionalized 2,3,4- and 1,2,3,4- substituted pyrroles
Gupton, John T.,Shimozono, Alex,Crawford, Evan,Ortolani, Joe,Clark, Evan,Mahoney, Matt,Heese, Campbell,Noble, Jeffrey,Mandry, Carlos Perez,Kanters, Rene,Dominey, Raymond N.,Goldman, Emma W.,Sikorski, James A.,Fisher, Daniel C.
, p. 2650 - 2663 (2018/04/23)
Highly functionalized pyrroles with appropriate regiochemical functionality represent an important class of marine natural products and potential drug candidates. We describe herein a detailed study of the reaction of α-aminoacid esters with vinylogous amides and also β-halovinylaldehydes for the regiospecific synthesis of 2,3,4-trisubstituted and 1,2,3,4-tetrasubstituted pyrroles. Since the vinylogous amides and β-halovinylaldehydes are readily available precursors, rapid access to a wide variety of unsymmetrically substituted pyrroles is accomplished via this methodology.
Studies on anti-platelet agents. IV. A series of 2-substituted 4,5-bis(4-methoxyphenyl)pyrimidines as novel anti-platelet agents
Tanaka,Motoyama,Takasugi
, p. 1828 - 1834 (2007/10/02)
The syntheses and structure-activity relationships of a series of 2-substituted 4,5-bis(4-methoxyphenyl)pyrimidines, designed on the basis of structural analyses of several cyclooxygenase (CO) inhibitors, and their derivatives as anti-platelet agents base