66670-98-2

Basic information

• Product Name: 2-(4-methoxyphenyl)-1,3-oxazolidine
• CAS NO: 66670-98-2
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179.2157
• Mol File: 66670-98-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 299.3°C at 760 mmHg
• Flash Point: 116.2°C
• Density: 1.092g/cm³
• Vapor Pressure: 0.0012mmHg at 25°C
• Refractive Index: 1.52
• CAS DataBase Reference: 2-(4-methoxyphenyl)-1,3-oxazolidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methoxyphenyl)-1,3-oxazolidine(66670-98-2)
• EPA Substance Registry System: 2-(4-methoxyphenyl)-1,3-oxazolidine(66670-98-2)

Safety Data

• Hazardous Substances Data: 66670-98-2(Hazardous Substances Data)

Usage

Description

2-(4-methoxyphenyl)-1,3-oxazolidine is a heterocyclic organic compound with the molecular formula C10H13NO2. It features a 4-methoxyphenyl group attached to the second carbon atom in the oxazolidine ring, which contains both nitrogen and oxygen atoms. 2-(4-methoxyphenyl)-1,3-oxazolidine is widely recognized for its role as a chiral auxiliary in asymmetric synthesis, particularly in the production of pharmaceuticals and agricultural chemicals. Its unique structure and properties make it a valuable tool for synthesizing complex organic molecules with specific stereochemistry, and it may also have potential applications in materials science and catalysis.

Uses

Used in Pharmaceutical Industry:
2-(4-methoxyphenyl)-1,3-oxazolidine is used as a chiral auxiliary in asymmetric synthesis for the production of pharmaceuticals. Its unique structure aids in creating complex organic molecules with specific stereochemistry, which is crucial for the development of effective and targeted drugs.
Used in Agricultural Chemicals Industry:
Similarly, in the agricultural chemicals industry, 2-(4-methoxyphenyl)-1,3-oxazolidine serves as a chiral auxiliary in asymmetric synthesis. This helps in the production of agrochemicals with precise molecular structures, ensuring their effectiveness and selectivity in pest control and crop protection.
Used in Materials Science:
2-(4-methoxyphenyl)-1,3-oxazolidine may also be utilized in materials science for the development of new materials with specific properties. Its unique structure can contribute to the creation of materials with tailored characteristics for various applications.
Used in Catalysis:
In the field of catalysis, 2-(4-methoxyphenyl)-1,3-oxazolidine has potential applications due to its ability to influence the stereochemistry of reactions. This can be beneficial in developing more efficient and selective catalytic processes for industrial chemical transformations.

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 141-43-5 ethanolamine 

Downstream Products

• 13676-94-3 2-(4-methoxyphenyl)-4,5-dihydrooxazole 
• 5772-17-8 2,2'-bis-(4-methoxy-phenyl)-3,3'-malonyl-bis-oxazolidine 

Relevant articles and documents

Fragment splicing-based design, synthesis and safener activity of novel substituted phenyl oxazole derivatives

Fragment splicing is a primary strategy in the design and optimization of leading compound toward new skeleton with target bioactivity. Herein a series of novel substituted phenyl oxazole derivatives were designed via fragment analysis and coupling strategy that led to highly potent and bio-selective herbicide safener. The biological tests showed that most of the compounds could enhance the maize growth index, glutathione content and anti-reverse enzyme glutathione S-transferase activity in vivo. The molecular docking model exhibited that the novel compound could compete with chlorsulfuron binding to the herbicide target enzyme, which consequently attained the herbicide detoxification. Especially compound I-f displayed the best activities than commercial safener isoxadifen-ethyl and other compounds. The present work demonstrates that the synthesized compounds could be developed as potential candidates for the discovery of novel herbicide safeners in the future.