13676-94-3

Basic information

• Product Name: Oxazole, 4,5-dihydro-2-(4-methoxyphenyl)-
• CAS NO: 13676-94-3
• Molecular Formula: C10H11NO2
• Molecular Weight: 177.203
• Mol File: 13676-94-3.mol
• Article Data: 36

Chemical Properties

• CAS DataBase Reference: Oxazole, 4,5-dihydro-2-(4-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Oxazole, 4,5-dihydro-2-(4-methoxyphenyl)-(13676-94-3)
• EPA Substance Registry System: Oxazole, 4,5-dihydro-2-(4-methoxyphenyl)-(13676-94-3)

Safety Data

• Hazardous Substances Data: 13676-94-3(Hazardous Substances Data)

Upstream product

• 57728-69-5 N-(2-hydroxyethyl)-p-methoxybenzamide 
• 1952-35-8 2-(p-methoxybenzylideneamino)ethanol 
• 123-11-5 4-methoxy-benzaldehyde 
• 141-43-5 ethanolamine 
• 66670-98-2 2-(4-methoxy-phenyl)-oxazolidine 
• 25393-52-6 3-(4-Methoxybenzoyl)-2-oxazolidinone 
• 119072-55-8 tert-butylisonitrile 
• 696-62-8 para-iodoanisole 
• 66107-29-7 4-methoxyphenyl triflate 
• 96316-04-0 N-(2-hydroxyethyl)-4-methoxybenzothioamide 
• 2362-64-3 p-methoxythiobenzamide 
• 81428-58-2 4-(4,5-dihydro-2-oxazolyl)phenol 
• 74-88-4 methyl iodide 
• 1943-83-5 2-chloroethyl isothiocyanate 

Downstream Products

• 81592-58-7 Trifluoro-methanesulfonate2-(4-methoxy-phenyl)-3-methyl-4,5-dihydro-oxazol-3-ium; 
• 1119513-05-1 bis-(2-[p-anisolyl]-2-oxazoline-κ1N) zinc(II) bromide 
• 1119512-98-9 bis-(2-[p-anisolyl]-2-oxazoline-κ1N) zinc(II) chloride 
• 1082928-23-1 3-(4-methoxybenzamido)propanal 
• 99-87-6 4-methylisopropylbenzene 

Relevant articles and documents

Visible Light-Promoted Aryl Azoline Formation over Mesoporous Organosilica as Heterogeneous Photocatalyst

N-heterocyclic compounds demonstrate wide applications ranging from natural compound production to coordination chemistry. Usually, the synthesis of N-heterocyclic compounds is conducted under thermal conditions, mostly by Lewis acids or metal-containing compounds as molecular catalysts. Here, we report a photocatalytic route for aryl azoline formation by mesoporous organosilica as visible light-active and heterogeneous photocatalyst. Via formation of aromatic aldehydes with various amines, 2-phenyl-2-imidazoline, 2-phenyl-2-oxazoline, 2-phenyl-2-thiazoline and their derivatives could be formed with high conversion and selectivity. Additionally, the organosilica photocatalyst showed high stability and reusability.

Facile one-pot synthesis of 2-oxazoline

We developed a facile one-pot synthesis of 2-oxazolines from carboxylic acid and 2-chloroethyl isocyanate, involving amide bond formation and a following intramolecular cyclization using 4-dimethylaminopyridine as the catalyst. A large variety of functional groups are well tolerated by the mild reaction conditions to afford diverse 2-oxazolines in good to excellent yields. This reaction will keep the chirality of the isocyanate at position 1, the R2 substituted carbon. Microwave-assisted synthesis can further enhance the reaction yield and reduce the reaction time to 5 min. This method facilities the synthesis of 2-oxazolines for diverse applications, such as 2-oxazoline derived polymers and materials.

Rhodium(III)-Catalyzed Oxidative Cyclization of Oxazolines with Cyclopropanols: Synthesis of Isoindolinones

The synthesis of C3-substituted isoindolin-1-ones from oxazolines and cyclopropanols has been achieved with oxazoline as a bifunctional nucleophilic directing group. The reaction proceeds by the cleavage of three chemical bonds and allows the formation of three new chemical bonds, a C-N bond, a C-C bond, and a C-O bond, in a single step.