66675-22-7

Basic information

• Product Name: 1H-IMidazole, 2-(trifluor...
• Synonyms: 1H-IMidazole, 2-(trifluor...;1H-IMidazole, 2-(trifluoroMethyl)-;2-(trifluoroMethyl)iMidazole
• CAS NO: 66675-22-7
• Molecular Formula: C4H3F3N2
• Molecular Weight: 136.08
• Mol File: 66675-22-7.mol
• Article Data: 8

Chemical Properties

• Melting Point: 145-147 °C(Solv: chloroform (67-66-3))
• Boiling Point: 186.1±40.0 °C(Predicted)
• Appearance: /
• Density: 1.440±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 10.65±0.10(Predicted)
• CAS DataBase Reference: 1H-IMidazole, 2-(trifluor...(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-IMidazole, 2-(trifluor...(66675-22-7)
• EPA Substance Registry System: 1H-IMidazole, 2-(trifluor...(66675-22-7)

Safety Data

• Hazardous Substances Data: 66675-22-7(Hazardous Substances Data)

Usage

Description

1H-IMidazole, 2-(trifluoromethyl)-1H-imidazole, also known as 2-trifluoromethylimidazole, is an organic compound that belongs to the imidazole family. It is characterized by the presence of a trifluoromethyl group attached to the imidazole ring. 1H-IMidazole, 2-(trifluor... is known for its unique chemical properties and potential applications in various fields.

Uses

Used in Pharmaceutical Industry:
1H-IMidazole, 2-(trifluoromethyl)-1H-imidazole is used as an intermediate in the synthesis of sulfonamide derivatives. These derivatives have potential applications as amyloid β production inhibitors, which are useful in treating or preventing diseases related to amyloid β (Aβ) protein aggregation, such as Alzheimer's disease.

Upstream product

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Relevant articles and documents

Novel nitroimidazole drug as well as preparation method and application of novel nitroimidazole drug

The invention relates to a novel nitroimidazole compound as well as a preparation method and application of the novel nitroimidazole compound to medical science and specifically relates to a nitroimidazole compound as shown in a general formula (I), a preparation method of the nitroimidazole compound and a pharmaceutical composition containing the compound. The invention aims at synthesizing a novel compound of a series of nitroimidazole derivatives by modifying the structure of a nitroimidazole compound, the compound can be used for obviously reducing adverse reaction in clinic, meanwhile, the compound has a relatively ideal effect on protecting the liver and kidneys, and the clinical application of the compound is apparent.

A convenient synthesis of perfluoroalkylated and fluorinated-aryl nitrogen bases by electrochemically induced SRN1 substitution

Indirect electrochemical reduction, by means of an aromatic anion mediator, of perfluoroalkyl halides (CF3Br, n-C4F9I, n-C6F13I, I(CF2)4I) in the presence of imidazole, 4(5)-nitroimidazole, 2-methyl-5-nitroimidazole, 2-(4′-methoxyphenyl)imidazole, imidazole-2-carboxaldehyde, 4(5)-nitroimidazole-2-carboxaldehyde, 5(6)-nitrobenzimidazole, purines (adenine, hypoxanthine, xanthine, theophylline, lumazine) and pyrimidine anions (uracil, cytosine, barbituric acid) yields the corresponding C-perfluoroalkylated nitrogen bases by an SRN1 mechanism. Aromatic nucleophilic substitution of some fluorinated aryl halides 1-iodo-2-(trifluoromethyl)benzene and 1-(4′-iodo-tetrafluorophenyl)-imidazole was also investigated and it was found that 1-iodo-2-(trifluoromethyl)benzene could react successfully under redox-catalyzed conditions with imidazole, 2-(4′-methoxyphenyl)imidazole anion, and uracil anion to give the corresponding 5-(fluorinated-aryl) nitrogen bases. In the case of 1-(4′-iodo-tetrafluorophenyl)imidazole, direct electrochemical radical nucleophilic substitution with 2-methyl-5-nitroimidazole and uracil was possible in DMSO. In this way new, 4-[2′,3′,5′,6′-tetrafluoro-4′-(imidazol-1″- yl)phenyl] nitrogen bases were obtained in good yields.

Electrochemically Induced Nucleophilic Substitution of Perfluoroalkyl Halides. An Example of a Dissociative Electron-Transfer-Induced Chemical Reaction

Nucleophilic substitution of perfluoroalkyl halides can be induced electrochemically.The reaction mechanism is a slightly modified version of the classical SRN1 mechanism in which the reaction is triggered by dissociative electron transfer, not