66715-59-1

Basic information

• Product Name: 2,3-dihydro-8-methoxy-4H-1-benzothiopyran-4-one
• Synonyms: 2,3-dihydro-8-methoxy-4H-1-benzothiopyran-4-one;8-methoxythiochroman-4-one
• CAS NO: 66715-59-1
• Molecular Formula: C₁₀H₁₀O₂S
• Molecular Weight: 194.2502
• EINECS: 266-458-0
• Mol File: 66715-59-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 344.2°C at 760 mmHg
• Flash Point: 172.1°C
• Appearance: /
• Density: 1.243g/cm³
• Vapor Pressure: 6.7E-05mmHg at 25°C
• Refractive Index: 1.599
• CAS DataBase Reference: 2,3-dihydro-8-methoxy-4H-1-benzothiopyran-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-dihydro-8-methoxy-4H-1-benzothiopyran-4-one(66715-59-1)
• EPA Substance Registry System: 2,3-dihydro-8-methoxy-4H-1-benzothiopyran-4-one(66715-59-1)

Safety Data

• Hazardous Substances Data: 66715-59-1(Hazardous Substances Data)

Usage

General Description

2,3-Dihydro-8-methoxy-4H-1-benzothiopyran-4-one is a chemical compound with the molecular formula C11H10O3S. It is a benzothiopyran derivative with a methoxy group attached to the 8th carbon atom. 2,3-Dihydro-8-methoxy-4H-1-benzothiopyran-4-one has been studied for its potential pharmaceutical properties, particularly its anti-inflammatory and anti-cancer activities. It is also known for its role as a precursor in the synthesis of various organic compounds. This chemical compound is of interest to researchers for its potential applications in the development of new drugs and related products.

InChI:InChI=1/C10H10O2S/c1-12-9-4-2-3-7-8(11)5-6-13-10(7)9/h2-4H,5-6H2,1H3

Upstream product

• 7217-59-6 2-Methoxybenzenethiol 
• 66715-58-0 3-(2-methoxyphenylsulfanyl)-propanoic acid 
• 10026-13-8 phosphorus pentachloride 

Downstream Products

• 132778-45-1 8-methoxy-thiochroman-4-one-(2,4-dinitro-phenylhydrazone) 

Relevant articles and documents

Synthesis and anticancer activities of thiosemicarbazones derivatives of thiochromanones and related scaffolds

A series of novel thiosemicarbazone analogs (4a–t, 6a–j) were synthesized and evaluated for their cytotoxic activities. The obtained results showed that thiochromanone-based thiosemicarbazones substituted primarily at the C-8 position exhibited higher cytotoxicity than the corresponding 1,1-dioxo-thiochromanone-, benzothiazepine-, and 1,1-dioxo-benzothiazepine-based analogs. Significantly, compound 4c (8-fluoro thiochromanone thiosemicarbazone) was found to be the most active and exhibited potent cytotoxicity against the MCF-7, SK-mel-2, and DU145 cancer cell lines, with IC50 values of 0.42, 0.58, and 0.43 μM, respectively. In addition, the mechanism of compound 4c induced MCF-7 cell apoptosis was preliminarily investigated through cell cycle, Annexin V-FITC/PI staining, and ROS assays, indicating that compound 4c may exert its anticancer property through ROS-mediated apoptosis.

TRICYCLIC PYRAZOL AMINE DERIVATIVES

This invention relates to compounds of Formula (I*) as Pi3k inhibitors for treating autoimmune diseases, inflammatory disorders, multiple sclerosis and other diseases like cancers.