66737-88-0

Basic information

• Product Name: 3-TERT-BUTYL-4-HYDROXYBENZOIC ACID
• Synonyms: 3-TERT-BUTYL-4-HYDROXYBENZOIC ACID;3-TERT-BUTYL-4-HYDROXYBENZOIC ACID 97%
• CAS NO: 66737-88-0
• Molecular Formula: C₁₁H₁₄O₃
• Molecular Weight: 194.23
• EINECS: 200-589-5
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
• Mol File: 66737-88-0.mol
• Article Data: 6

Chemical Properties

• Melting Point: 157-159°C
• Boiling Point: 331.4±35.0 °C(Predicted)
• Appearance: /
• Density: 1.162±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.67±0.10(Predicted)
• CAS DataBase Reference: 3-TERT-BUTYL-4-HYDROXYBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-TERT-BUTYL-4-HYDROXYBENZOIC ACID(66737-88-0)
• EPA Substance Registry System: 3-TERT-BUTYL-4-HYDROXYBENZOIC ACID(66737-88-0)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-52-41-37/38-22
• Safety Statements: 26-36/37/39-39
• Hazardous Substances Data: 66737-88-0(Hazardous Substances Data)

Usage

General Description

3-tert-Butyl-4-hydroxybenzoic acid, also known as 3-(tert-Butyl)-4-hydroxybenzoic acid, is a chemical compound with the molecular formula C11H14O3. It is categorized under the chemical class called Benzoic acids and derivatives, which are compounds containing a benzene ring which bears at least one carboxyl group. It possesses antioxidative properties, making it useful in various oxidative stress research. 3-TERT-BUTYL-4-HYDROXYBENZOIC ACID is also known for its use in the design and synthesis of various pharmaceuticals and natural product-like compounds. Its physical characteristics or hazard information may vary and should be handled carefully following respective safety procedures.

Upstream product

• 4910-04-7 3-(1,1-dimethylethyl)-4-hydroxybenzonitrile 
• 1421-49-4 3,5-Di-tert-butyl-4-hydroxybenzoic acid 
• 150094-87-4 2-tert-butyl-1-methoxymethoxy-4-methylbenzene 
• 2409-55-4 2-tert-Butyl-4-methylphenol 
• 66737-89-1 3-(tert-butyl)-4-methoxybenzoic acid 
• 10323-39-4 4-bromo-2-tert-butylphenol 
• 88-18-6 2-tert-Butylphenol 
• 39778-63-7 3-(1,1-dimethylethyl)-4-hydroxybenzoic acid methyl ester 

Downstream Products

• 147219-64-5 3-(1,1-dimethylethyl)-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>benzoic acid (1,1-dimethylethyl)dimethylsilyl ester 
• 39778-63-7 3-(1,1-dimethylethyl)-4-hydroxybenzoic acid methyl ester 
• 882500-52-9 3-(tert-butyl)-5-formyl-4-hydroxybenzoic acid 
• 882500-53-0 methyl-3-tert-butyl-5-formyl-4-hydroxybenzoate 
• 912999-01-0 2-(3-tert-butyl-4-hydroxybenzoyl)-2,3-dihydro-1H-isoindole 
• 628337-20-2 1-(6-benzyloxy-5-tert-butyl-4'-methyl-3-biphenylyl)prop-2-yn-1-ol 
• 628337-18-8 methyl 6-benzyloxy-5-tert-butyl-4'-methyl-3-biphenylcarboxylate 
• 628337-22-4 1-(6-benzyloxy-5-tert-butyl-4'-methyl-3-biphenylyl) ethanone 
• 628337-19-9 6-benzyloxy-5-tert-butyl-4'-methyl-3-biphenylcarbaldehyde 
• 628337-17-7 methyl 4-benzyloxy-3-tert-butyl-5-iodobenzoate 
• 628337-16-6 methyl 3-tert-butyl-4-hydroxy-5-iodobenzoate 
• 628337-14-4 4-[3-(6-benzyloxy-5-tert-butyl-4'-methyl-3-biphenylyl)-3-hydroxy-1-propynyl]benzoic acid 
• 628337-21-3 4-[(E)-3-(6-benzyloxy-5-tert-butyl-4'-methyl-3-biphenylyl)-3-oxo-propenyl]benzoic acid 

Relevant articles and documents

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CATHEPSIN S INHIBITORS

Compounds of the formula (I) where R1 is C1-C4 straight or branched alkyl, optionally substituted with up to three substituents selected from halo and hydroxy; R2 is halo, hydroxy, methyloxy, or C1-C2 alkyl, which alkyl is optionally substituted with up to three halogens or an hydroxy or a methyloxy; D is - C3-C7 alkylene-, thereby defining a cycloalkyl ring; E is -C(=O)-, -S(=O)m-, -NRdS(=O)m-, -NRaC(=O)-, -OC(=O)-, R3 is an optionally substituted carbocyclic or heterocyclic ring R10 is H, ORc, SRc or together with the gem H is =O or (ORc)2; Ra is independently selected from H, C1-C4 alkyl; have utility in the inhibition of cathepsin S and are thus useful pharmaceuticals against disorders such as autoimmune disorders and chronic pain.