66737-89-1Relevant articles and documents
BICYCLIC COMPOUNDS USEFUL AS CATHEPSIN S INBHIBITORS
-
Page/Page column 38, (2010/11/29)
Compounds of formula (I), wherein R1, R2, R3, Ra and E are are defined within, and pharmaceutically acceptable salts, solvates, hydrates and N-oxides thereof having utility in the treatment of disorders mediated by cathepsin S.
Substituted cycloalkylamine derivatives as modulators of chemokine receptor activity
-
Page/Page column 37, (2010/02/11)
The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma, multiple sclerosis, artherosclerosis, and rheumatoid arthritis.
Benzo (b) thiophene carboxylate derivatives and pharmaceutical compositions
-
, (2008/06/13)
Aromatic heterocyclic derivatives have the formula STR1 wherein R1 represents STR2 wherein R3 represents hydrogen, --OR4 wherein R4 represents hydrogen, alkyl having 1-20 carbon atoms or mono- or polyhydroxyalkyl or R3 represents STR3 wherein r' and r" represent hydrogen, lower alkyl or together form a heterocycle, R2 represents hydrogen or --CH3 and Ar represents STR4 wherein Z is O or S, STR5 wherein R5 is lower alkyl or STR6 wherein R6 is hydrogen or alkyl having 1-10 carbon atoms and R7 represents alkyl having 4-12 carbon atoms or cycloalkyl, Y is CH or a nitrogen atom and X represents oxygen, sulfur or --N--R8 when R8 represents hydrogen, lower alkyl or lower alkoxycarbonyl, with the proviso that (i) when Y is CH and X is oxygen or sulfur Ar is other than C and (ii) when Y is nitrogen and X is oxygen, Ar is other than (C) or (D) in which R6 is alkyl having 1-4 carbon atoms and R7 is branched alkyl having 4-12 atoms useful in veterinary or human therapy and in cosmetic formulations.