66774-84-3

Basic information

• Product Name: de-A,B-25-hydroxycholestan-8β-ol
• Synonyms: de-A,B-25-hydroxycholestan-8β-ol
• CAS NO: 66774-84-3
• Molecular Weight: 282.467
• Mol File: 66774-84-3.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: de-A,B-25-hydroxycholestan-8β-ol(CAS DataBase Reference)
• NIST Chemistry Reference: de-A,B-25-hydroxycholestan-8β-ol(66774-84-3)
• EPA Substance Registry System: de-A,B-25-hydroxycholestan-8β-ol(66774-84-3)

Safety Data

• Hazardous Substances Data: 66774-84-3(Hazardous Substances Data)

Usage

Uses

(εR,1R,3aR,4S,7aR)-Octahydro-4-hydroxy-α,α,ε,7a-tetramethyl-1H-indene-1-pentanol is an intermediate in synthesizing (1α,3β,9β)-Cholesta-5,7-diene-1,3,25-triol (C431410), which is a natural secondary steroid used to determine the signal transduction pathways for rapid and genomic responses to calcitriol discrimination between different agonist shapes.

Upstream product

• 70550-66-2 <1R-<1β(R*),3aα,4β,7aβ>>-Octahydro-4-acetoxy-α,α,ε,7a-tetramethyl-1H-indene-1-pentanol 
• 33813-99-9 Grundmann's alcohol 
• 917-54-4 methyllithium 
• 100928-07-2 8β-hydroxy-de-A,B-27-norcholestan-25-one 
• 70550-65-1 Acetic acid (1R,3aR,4S,7aR)-1-((R)-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-4-yl ester 
• 75-16-1 methylmagnesium bromide 
• 135359-40-9 de-A,B-24-(methoxycarbonyl)-cholestan-8β-ol 
• 64190-52-9 (8S,20S)-de-A,B-20-(hydroxymethyl)pregnan-8-ol 
• 116535-65-0 (1R,3aR,4S,7aR)-octahydro-1-[(S)-1-iodopropan-2-yl]-7a-methyl-1H-inden-4-ol 
• 74-88-4 methyl iodide 
• 146434-16-4 <1R-<1α(R^*),3aβ,4α,7aα>>-octahydro-4-hydroxy-δ,7a-dimethyl-1H-indene-1-pentanoic acid ethyl ester 
• 917-64-6 methyl magnesium iodide 
• 300344-32-5 (8S,20S)-de-A,B-8-triethylsilyloxy-20-(iodomethyl)-pregnane 
• 93489-60-2 <1R-<1β(R*),3aα,4β,7aβ>>-octahydro-4-hydroxy-β,7a-dimethyl-1H-indene-1-propanenitrile 

Downstream Products

• 70550-73-1 (1R,3aR,7aR)-1-[(2R)-6-hydroxy-6-methylhept-2-yl]-7a-methyloctahydroinden-4-one 
• 130759-99-8 (R)-1-[(1S,3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohexyl]-2-[(1R,3aS,7aR)-1-[(R)-5-(tert-butyl-dimethyl-silanyloxy)-1,5-dimethyl-hexyl]-7a-methyl-octahydro-inden-(4E)-ylidene]-ethanol 
• 130760-01-9 (1R,3S,5R)-5-{(E)-2-[(1R,7aR)-1-((R)-5-Hydroxy-1,5-dimethyl-hexyl)-7a-methyl-2,3,5,6,7,7a-hexahydro-1H-inden-4-yl]-vinyl}-4-methylene-cyclohexane-1,3-diol 
• 32222-06-3 calcitriol 
• 144848-24-8 25-[(triethylsilyl)oxy]de-A,B-cholestan-8-one 
• 249928-69-6 C₃₁H₅₀O₃(SiC₆H₁₄)3 

Relevant articles and documents

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VITAMIN D3 DERIVATIVES AND PHARMACEUTICAL USE THEREOF

The present invention relates to vitamin D3 derivatives of the following formula, wherein each symbol has the same meaning as defined herein, and pharmaceutical or medical use thereof for treating metabolic disease, liver disease, obesity, diabetes, cardiovascular disease, or cancer in a patient in need thereof.

Synthesis of novel hapten derivatives of 1α,25-dihydroxyvitamin D3 and its 20-epi analogue

Hapten derivatives of 1α,25-dihydroxyvitamin D3 and its 20-epimer were synthesized and conjugated to a carrier protein for raising polyclonal antibodies. The haptens were linked through spacers at C-16, thereby exposing both the A-ring and the side chain of the molecules, to maximize antibody specificity. The spacers were introduced via stereoselective hydroboration of 16-ene intermediates as the key step. In immunoassays, the antibodies raised toward the natural hormone were selective to this compound over derivatives with modifications in the A-ring or the side chain. The antibodies toward the 20-epimer, however, were unable to recognize modifications in the side chain.