67074-64-0

Basic information

• Product Name: 2(1H)-Quinoxalinone,3,4-dihydro-1,3-dimethyl-(9CI)
• Synonyms: 2(1H)-Quinoxalinone,3,4-dihydro-1,3-dimethyl-(9CI);1,3-DIMETHYL-3,4-DIHYDROQUINOXALIN-2(1H)-ONE
• CAS NO: 67074-64-0
• Molecular Formula: C10 H12 N2 O
• Molecular Weight: 176.22
• Product Categories: PIPERIDINE
• Mol File: 67074-64-0.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2(1H)-Quinoxalinone,3,4-dihydro-1,3-dimethyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Quinoxalinone,3,4-dihydro-1,3-dimethyl-(9CI)(67074-64-0)
• EPA Substance Registry System: 2(1H)-Quinoxalinone,3,4-dihydro-1,3-dimethyl-(9CI)(67074-64-0)

Safety Data

• Hazardous Substances Data: 67074-64-0(Hazardous Substances Data)

Usage

Structure

A heterocyclic compound with a benzene ring fused to a pyrazine ring, two methyl groups at positions 3 and 4

Biological properties

Potential applications in drug development and medicinal chemistry

Pharmacological activities

Considerable research has been conducted on its potential therapeutic applications

Scientific interest

Unique structure and properties make it an intriguing subject of study for those interested in the synthesis of quinoxalinone derivatives.

Upstream product

• 3149-25-5 1,3-dimethyl-1H-quinoxalin-2-one 

Relevant articles and documents

Rhodium-catalyzed transfer hydrogenation of quinoxalines with water as a hydrogen source

Rhodium-catalyzed transfer hydrogenation of quinoxalines with water as a hydrogen source was reported. The reaction allowed the simple preparation of tetrahydroquinoxalines under mild conditions. The deuterium-labelling experiment confirmed that water is

Versatile (Pentamethylcyclopentadienyl)rhodium-2,2′-Bipyridine (Cp?Rh-bpy) Catalyst for Transfer Hydrogenation of N-Heterocycles in Water

An investigation employing the catalytic system consisting of (pentamethylcyclopentadienyl)rhodium dichloride dimer [Cp?RhCl2]2 and 2,2′-bipyridine (bpy) for transfer hydrogenation of a variety of quinoxalines, quinoxalinones, quinolines and indoles under aqueous conditions with formate as the hydrogen source is reported. This approach provides various tetrahydroquinoxalines, dihydroquinoxalinones, tetrahydroquinolines and indolines in good to excellent yields. The activity of the catalyst towards quinoxalines and quinoxalinones is excellent, with a substrate to catalyst ratio (S/C) of 10000 being feasible. The choice of ligand is critical to the catalysis, and the aqueous phase reduction is shown to be highly pH-dependent, with acidic pH values needed for optimal reduction. The catalyst is easy to access, and the reaction is operationally simple without requiring an inert atmosphere.