67228-76-6

Basic information

• Product Name: 2-Propynal, 3-(4-chlorophenyl)-
• CAS NO: 67228-76-6
• Molecular Formula: C9H5ClO
• Molecular Weight: 164.591
• Mol File: 67228-76-6.mol
• Article Data: 19

Chemical Properties

• CAS DataBase Reference: 2-Propynal, 3-(4-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propynal, 3-(4-chlorophenyl)-(67228-76-6)
• EPA Substance Registry System: 2-Propynal, 3-(4-chlorophenyl)-(67228-76-6)

Safety Data

• Hazardous Substances Data: 67228-76-6(Hazardous Substances Data)

Upstream product

• 873-73-4 4-n-chlorophenylacetylene 
• 68-12-2 N,N-dimethyl-formamide 
• 637-87-6 1-Chloro-4-iodobenzene 
• 104-88-1 4-chlorobenzaldehyde 
• 37614-57-6 3-(4-chlorophenyl)prop-2-yn-1-ol 
• 77295-59-1 1-chloro-4-(2,2-dibromovinyl)benzene 

Downstream Products

• 78076-18-3 C₁₇H₁₁ClO₂ 
• 639850-09-2 N-[3-(4-chlorophenyl)prop-2-ynylidene]-P,P-diphenylphosphinamide 
• 67228-19-7 Fe(CO)2(P(OCH₃)3)2SCSC₂(C₆H₄Cl)(CHO) 
• 1071813-78-9 C₉H₆ClN₃O 
• 1228931-76-7 methyl 5-(4-chlorophenyl)-3-hydroxy-2-methylene-pent-4-ynoate 
• 1257518-26-5 4-(4-chlorophenylethynyl)oxetan-2-one 
• 1392207-19-0 p-chlorophenylbuta-1,3-diynyl methyl sulfide 
• 1446871-26-6 (E)-1-methylthio-1-phenylsulphonyl-(4-(4-chloro)phenyl)-1-butene-3-yne 
• 1402579-13-8 C₂₂H₂₃ClO₅ 
• 1402578-89-5 C₂₀H₁₉ClO₅ 

Relevant articles and documents

Synthesis of Chiral Propargylamines, Chiral 1,2-Dihydronaphtho[2,1-b]furans and Naphtho[2,1-b]furans with C-Alkynyl N,N′-di-(tert-butoxycarbonyl)-aminals and β-Naphthols

Chiral phosphoric acid-catalyzed couplings of C-alkynyl N,N′-di-(tert-butoxycarbonyl)-aminals with β-naphthols led to chiral propargylamines in moderate to high yields with high to excellent enantioselectivity, in which the reactions underwent sequential chiral phosphoric acid-catalyzed in situ formation of N-(tert-butoxycarbonyl)-imines (N-Boc-imines) from the aminals, and 1,2-addition of β-naphthols to the N-Boc-imines. Chiral 1,2-dihydronaphtho[2,1-b]furans and naphtho[2,1-b]furans were prepared with satisfactory results when 10 mol% AgOAc and 20 mol% 2,6-lutidine or 1.2 equiv. of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) were added to the resulting chiral propargylamines solution, respectively.

Transition-metal-free and facile synthesis of 3-alkynylpyrrole-2,4-dicarboxylates from methylene isocyanides and propiolaldehyde

A transition-metal-free, facile and efficient method for the synthesis of 3-alkynylpyrrole-2,4-dicarboxylates from methylene isocyanides and propiolaldehyde with moderate to good yields has been developed. The direct transformation process and good tolerance of various substituents make it an alternative approach to previous protocols, and potential applications of these investigated compounds are expected with or without post-modifications.

Copper-Catalyzed Asymmetric Silylation of Propargyl Dichlorides: Access to Enantioenriched Functionalized Allenylsilanes

A copper-catalyzed silylation of propargyl dichlorides was developed to access chloro-substituted allenylsilanes under mild reaction conditions. Moreover, enantioenriched chloro-substituted allenylsilanes can be synthesized in moderate to high yields and good enantioselectivities with this protocol.