37614-57-6

Basic information

• Product Name: 3-(4-CHLORO-PHENYL)-PROP-2-YN-1-OL
• Synonyms: AKOS PRN-0003;3-(4-CHLORO-PHENYL)-PROP-2-YN-1-OL;3-(4-Chlorophenyl)-2-propyn-1-ol
• CAS NO: 37614-57-6
• Molecular Formula: C₉H₇ClO
• Molecular Weight: 166.6
• Mol File: 37614-57-6.mol
• Article Data: 71

Chemical Properties

• Boiling Point: 272.5 °C at 760 mmHg
• Flash Point: 118.6 °C
• Appearance: /
• Density: 1.26 g/cm³
• Vapor Pressure: 0.00297mmHg at 25°C
• Refractive Index: 1.601
• CAS DataBase Reference: 3-(4-CHLORO-PHENYL)-PROP-2-YN-1-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-CHLORO-PHENYL)-PROP-2-YN-1-OL(37614-57-6)
• EPA Substance Registry System: 3-(4-CHLORO-PHENYL)-PROP-2-YN-1-OL(37614-57-6)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 37614-57-6(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Synthesis, p. 728, 1984 DOI: 10.1055/s-1984-30947

InChI:InChI=1/C9H7ClO/c10-9-5-3-8(4-6-9)2-1-7-11/h3-6,11H,7H2

Upstream product

• 107-19-7 propargyl alcohol 
• 536-74-3 phenylacetylene 
• 3240-10-6 (4-chlorophenyl)propiolic acid 
• 106-39-8 bromochlorobenzene 
• 50-00-0 formaldehyd 
• 78704-49-1 1-(4-chlorophenyl)-2-trimethylsilylacetylene 
• 19070-80-5 n-<(trimethylsiloxy)methyl>phthalimide 
• 637-87-6 1-Chloro-4-iodobenzene 
• 7681-65-4 copper(I) iodide 
• 109-89-7 diethylamine 
• 10534-59-5 tetrabutylammonium acetate 
• 873-73-4 4-n-chlorophenylacetylene 

Downstream Products

• 41412-82-2 1-chloro-4-(3-chloroprop-1-ynyl)benzene 
• 173019-82-4 1-(3-bromo-prop-1-ynyl)-4-chloro-benzene 
• 37614-53-2 [(Ξ)-4-((E)-4-chloro-benzylidene)-3-isopropyl-oxazolidin-2-ylidene]-isopropyl-amine 
• 873-73-4 4-n-chlorophenylacetylene 
• 208183-97-5 2-[3-(4-Chloro-phenyl)-prop-2-ynyloxy]-isoindole-1,3-dione 
• 67228-76-6 4-chlorophenylpropynal 
• 175219-73-5 (Z)-3-(4-chlorophenyl)prop-2-en-1-ol 
• 24583-70-8 (E)-3-(p-chlorophenyl)prop-2-en-1-ol 
• 1009089-47-7 1‐benzyl‐4‐(4‐chlorophenyl)‐1H‐1,2,3‐triazole 
• 59843-58-2 3-(4-chlorophenyl)-1H-pyrazole 

Relevant articles and documents

Bi(OTf)3-catalyed One-pot Synthesis of α-Halo-β-amino Ketones and Acyl Aziridines from 3-Aryl Propargyl Alcohols

A Bi(OTf)3-catalyed reaction of 3-aryl propargyl alcohols with sulfonamide and halogen source was firstly investigated, which provided a facile route for the synthesis of a large variety of α-halo-β-amino ketones. The key intermediates, β-amino

Copper-Catalyzed Cross-Nucleophile Coupling of β-Allenyl Silanes with Tertiary C-H Bonds: A Radical Approach to Branched 1,3-Dienes

Described herein is a distinctive approach to branched 1,3-dienes through oxidative coupling of two nucleophilic substrates, β-allenyl silanes, and hydrocarbons appending latent functionality by copper catalysis. Notably, C(sp3)-H dienylation proceeded in a regiospecific manner, even in the presence of competitive C-H bonds that are capable of occurring hydrogen atom transfer process, such as those located at benzylic and other tertiary sites, or adjacent to an oxygen atom. Control experiments support the intermediacy of functionalized alkyl radicals.

Transition-metal-free and facile synthesis of 3-alkynylpyrrole-2,4-dicarboxylates from methylene isocyanides and propiolaldehyde

A transition-metal-free, facile and efficient method for the synthesis of 3-alkynylpyrrole-2,4-dicarboxylates from methylene isocyanides and propiolaldehyde with moderate to good yields has been developed. The direct transformation process and good tolerance of various substituents make it an alternative approach to previous protocols, and potential applications of these investigated compounds are expected with or without post-modifications.