67247-12-5 Usage
Description
BOC-MET-LEU-PHE-OH, also known as Boc-MLF, is a chemotactic peptide antagonist derived from hydrolyzable tannins found in various plant sources. It is a white to off-white solid and possesses properties that enable it to act as an antagonist, preferentially inhibiting activity triggered through the formyl peptide receptor.
Uses
Used in Pharmaceutical Applications:
BOC-MET-LEU-PHE-OH is used as a chemotactic peptide antagonist for its ability to preferentially inhibit activity triggered through the formyl peptide receptor. This makes it a valuable compound in the development of pharmaceuticals targeting specific cellular responses and signaling pathways.
Used in Research and Development:
In the research and development industry, BOC-MET-LEU-PHE-OH is used as a tool to study the role of chemotactic peptides and their receptors in various biological processes. Its antagonistic properties allow researchers to investigate the effects of blocking specific receptor activities, which can lead to a better understanding of related diseases and potential therapeutic strategies.
Used in Drug Delivery Systems:
Similar to gallotannin, BOC-MET-LEU-PHE-OH could potentially be incorporated into novel drug delivery systems to enhance its applications and efficacy in targeted therapies. By employing various organic and metallic nanoparticles as carriers, the delivery, bioavailability, and therapeutic outcomes of BOC-MET-LEU-PHE-OH could be improved, making it a more effective compound in treating specific conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 67247-12-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,7,2,4 and 7 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 67247-12:
(7*6)+(6*7)+(5*2)+(4*4)+(3*7)+(2*1)+(1*2)=135
135 % 10 = 5
So 67247-12-5 is a valid CAS Registry Number.
InChI:InChI=1/C25H39N3O6S/c1-7-16(2)20(22(30)26-19(23(31)32)15-17-11-9-8-10-12-17)28-21(29)18(13-14-35-6)27-24(33)34-25(3,4)5/h8-12,16,18-20H,7,13-15H2,1-6H3,(H,26,30)(H,27,33)(H,28,29)(H,31,32)/t16?,18-,19-,20+/m0/s1
67247-12-5Relevant articles and documents
Chemo-enzymatic synthesis of optically active amino acids and peptides
Chen, Shui-Tein,Wang, Kung-Tsung
, p. 301 - 311 (2007/10/03)
The industrial alkaline protease, alcalase, is stable and active in a high concentration of organic solvents and useful as a biocatalyst for (i) diastereoselective hydrolysis of peptide esters and preparation of racemization-free peptides; (ii) selective incorporation of esters of D-amino acid into peptides in t-butanol via a selective hydrolysis of esters of D,L-amino acid, followed by using the unhydrolyzed D-esters as a nucleophile in a kinetically controlled peptide bond formation; (iii) resolution of esters of amino acid in 95% t-butanol/5% water, followed by saponification of the unreacted esters to offer both enantiomers with high yield and optical purity; (iv) completely resolve amino-acid esters with high yield and optical purity via in situ racemization of the unreacted antipode catalyzed by pyridoxal 5-phosphate; (v) cryobioorganic synthesis of peptides with increased yields 15%-40% of peptide bond formation by reaction at 5 °C instead of 25-30 °C of a kinetically controlled enzymatic reaction in alcohols.
Facile Synthesis of N-Protected Peptide Fragments using Polymer-Bound 1-Hydroxybenzotriazole as an Active Ester
Chen, Shui-Tein,Chang, Chung-Ho,Wang, Kung-Tsung
, p. 1967 - 1975 (2007/10/02)
Using polystyrene-bound 1-hydroxybenzotriazole as an active ester and an amino acid or peptide, temporarily C-terminal-protected by a phase-transfer reagent, as a nucleophile, C-terminal-free peptide fragments can be synthesized with very high yield and p
