3063-05-6

Basic information

• Product Name: H-LEU-PHE-OH
• Synonyms: L-LEUCYL-L-PHENYLALANINE;L-LEU-L-PHE;LEU-PHE;H-LEU-PHE-OH;(S)-α-[[(2S)-2-Amino-4-methylpentanoyl]amino]benzenepropanoic acid;Leu-Phe-OH;L-Leu-L-Phe-OH;N-Leucylphenylalanine
• CAS NO: 3063-05-6
• Molecular Formula: C₁₅H₂₂N₂O₃
• Molecular Weight: 278.35
• Product Categories: Amino Acid Derivatives
• Mol File: 3063-05-6.mol
• Article Data: 5

Chemical Properties

• Melting Point: 218-220 °C
• Boiling Point: 501.2°Cat760mmHg
• Flash Point: 256.9°C
• Appearance: /
• Density: 1.144g/cm³
• Vapor Pressure: 7.23E-11mmHg at 25°C
• Refractive Index: 1.544
• Storage Temp.: -15°C
• PKA: 3.41±0.10(Predicted)
• CAS DataBase Reference: H-LEU-PHE-OH(CAS DataBase Reference)
• NIST Chemistry Reference: H-LEU-PHE-OH(3063-05-6)
• EPA Substance Registry System: H-LEU-PHE-OH(3063-05-6)

Safety Data

• Hazardous Substances Data: 3063-05-6(Hazardous Substances Data)

Usage

Definition

ChEBI: A dipeptide formed from L-leucine and L-phenylalanine residues.

InChI:InChI=1/C15H22N2O3/c1-10(2)8-12(16)14(18)17-13(15(19)20)9-11-6-4-3-5-7-11/h3-7,10,12-13H,8-9,16H2,1-2H3,(H,17,18)(H,19,20)

Upstream product

• 76863-45-1 (S)-benzyl (1-azido-4-methyl-1-oxopentan-2-yl)carbamate 
• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 
• 26055-05-0 N-[N-(tert-butoxycarbonyl)-L-leucyl]-L-phenylalanine 
• 15136-32-0 (N-(tert-butoxycarbonyl)-L-leucinyl)-L-phenylalanine methyl ester 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 3005-89-8 ethyl N-benzyloxycarbonyl-L-leucyl-L-phenylalaninate 
• 3081-24-1 H-Phe-OEt 
• 63-91-2 L-phenylalanine 
• 3190-70-3 L-Leucin-N-carbonsaeureanhydrid 
• 6401-63-4 N-benzyloxycarbonyl-L-leucyl-L-phenylalanine 

Downstream Products

• 4156-30-3 Cyclo-(L)-leucyl-(D)-phenylalanyl 
• 3354-31-2 (3S,6S)-3-benzyl-6-isobutylpiperazine-2,5-dione 
• 38155-18-9 L-leucyl-L-phenylalanine methyl ester 
• 1194481-44-1 Cbz-AOGly-Gly-L-Leu-OH 
• 84759-78-4 2-[(S)-1-((S)-1-Methoxycarbonyl-2-phenyl-ethylcarbamoyl)-3-methyl-butylamino]-4-phenyl-butyric acid methyl ester 
• 110338-43-7 Boc-Gly-Ser-Lys(Z)-Val-Ile-Leu-Phe-OH 
• 110338-40-4 Boc-Lys-Val-Ile-Leu-Phe-OH 
• 110338-39-1 Z-Val-Ile-Leu-Phe-OH 
• 113965-80-3 (S)-2-{(S)-2-[(2S,3S)-2-((S)-2-Amino-3-methyl-butyrylamino)-3-methyl-pentanoylamino]-4-methyl-pentanoylamino}-3-phenyl-propionic acid 
• 259133-96-5 (S)-2-[(S)-2-((2S,3S)-2-Amino-3-methyl-pentanoylamino)-4-methyl-pentanoylamino]-3-phenyl-propionic acid 
• 110338-45-9 H-Gly-Ser-Lys(Z)-Val-Ile-Leu-Phe-OH_.TFA 
• 110338-38-0 Z-Ile-Leu-Phe-OH 
• 67247-12-5 tert-butyloxycarbonyl-methionyl-leucyl-phenylalanine 

Relevant articles and documents

Redox-triggered changes in the self-assembly of a ferrocene-peptide conjugate

Ultrasonication of a ferrocene conjugate of a short amyloid peptide (Aβ18-20) in toluene causes formation of an organogel, which undergoes dramatic structural changes upon oxidation from a nanofibrillar network to spherical micelles. This morphological change is redox-controlled and reversible. the Partner Organisations 2014.

DPP4 INHIBITOR AND PHARMACEUTICAL APPLICATION THEREOF

The present invention provides a Dpp4 inhibitor which comprises a leucine derivative of the following formula (1) or a methionine derivative of the following formula (2): wherein each R1 and R3 represents a hydrogen atom (H) and an L-amino acid residue; R2 represents a hydroxyl group (OH), alkoxy group having 1 to 6 carbon atoms, amino group (NH2), alkylamino group having 1 to 6 carbon atoms, glycine residue, β-alanine residue, L-amino acid (except for proline, alanine and phenylalanine) residue or L-amino-acid amide (except for proline amide, alanine amide and phenylalanine amide) residue; and R4 represents a hydroxyl group (OH), alkoxy group having 1 to 6 carbon atoms, amino group (NH2), alkylamino group having 1 to 6 carbon atoms, glycine residue, β-alanine residue, L-amino acid (except for proline and alanine) residue or L-amino-acid amide (except for proline amide and alanine amide) residue. These derivatives also act as autophagy regulators.

Peptides 119. - Peptide Synthesis with N-Carboxy-α-amino Acid Anhydrides

On reaction of N-carboxy-α-amino acid anhydrides (NCA) with equimolar amounts of aminoacids or excess NCA in potassium borate buffer of pH 10.2 (0 deg C) considerable amounts of homooligomers and homopolymers are formed.If an excess of amino acid is used formation of the above mentioned by-products can be suppressed.The extent of homooligomerization and homopolymerization and hydrolysis occurring during the reaction of NCA under the conditions of peptide synthesis is described.