67389-47-3Relevant articles and documents
Total synthesis of (-)-aplaminal
Smith III, Amos B.,Liu, Zhuqing
supporting information; experimental part, p. 4363 - 4365 (2009/06/06)
(Chemical Equation Presented) The total synthesis and assignment of absolute configuration of (-)-aplaminal (1), a cytotoxic metabolite from a sea hare possessing a triazobicyclo[3.2.1]octane skeleton, has been achieved. The synthesis entailed condensatio
Combinations of β3 agonists and growth hormone secretagogues
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Page column 96, (2008/06/13)
This invention is directed to pharmaceutical compositions comprising β3adrenergic agonists including (4-(2-(2-(6-aminopyridin-3-yl)-2(R)-hydroxyethylamino)ethoxy)phenyl)acetic acid and growth hormone or growth hormone secretagogues, prodrugs thereof or pharmaceutically acceptable salts of said compounds or said prodrugs. The invention is also directed to methods of using those compositions in the treatment of obesity, diabetes, hypertension and frailty in animals and particularly in humans.
Synthesis of an enantiomerically pure serine-derived thiazole
Sowinski, Jennifer A.,Toogood, Peter L.
, p. 7671 - 7676 (2007/10/03)
Previously reported methods for preparing enantiomerically pure thiazoles are inadequate for the synthesis of inherently labile O-alkyl serine-derived thiazoles. The intermediate N-Boc-(O-methylseryl) thiazolines are very susceptible to tautomerization, e