67531-86-6Relevant articles and documents
Palladium-catalyzed ortho-C-H hydroxylation of benzoic acids
Luo, Feihua,He, Shuhua,Gou, Quan,Chen, Jinyang,Zhang, mingzhong
, (2021/10/06)
A simple Pd(OAc)2 catalyzed ortho-hydroxylation of benzoic acids using TBHP as the sole oxidant has been explored. This protocol features relatively broad substrate scope and operational simplicity. The compatibility of ortho-substituted substrates is an effective complement to the previous ortho-hydroxylation reaction.
BORONIC ACID DERIVATIVES AND SYNTHESIS THEREOF
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Paragraph 0157; 0158, (2019/05/06)
Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the method of use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents, for example, β-lactamase inhibitors (BLIs).
Harnessing Enzymatic Promiscuity in Myxochelin Biosynthesis for the Production of 5-Lipoxygenase Inhibitors
Korp, Juliane,K?nig, Stefanie,Schieferdecker, Sebastian,Dahse, Hans-Martin,K?nig, Gabriele M.,Werz, Oliver,Nett, Markus
, p. 2445 - 2450 (2016/01/25)
The siderophore myxochelin A is a potent inhibitor of human 5-lipoxygenase (5-LO). To clarify whether the iron-chelating properties of myxochelin A are responsible for this activity, several analogues of this compound were generated in the native producer Pyxidicoccus fallax by precursor-directed biosynthesis. Testing in a cell-free assay unveiled three derivatives with bioactivity comparable with that of myxochelin A. Furthermore, it became evident that inhibition of 5-LO by myxochelins does not correlate with their iron affinities. A series of new myxochelin analogues was generated by precursor-directed biosynthesis. Some derivatives possess only weak iron-chelating properties, but are still potent inhibitors of human 5-lipoxygenase, an enzyme featuring a non-heme iron atom in its catalytically active site.
